Depletion of adult neurogenesis
exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition.
and modulation of neural circuit function.
Inflammation: a new candidate in modulating adult neurogenesis
According to the researchers, recent studies suggest adult neurogenesis
in the brain's subventricular zone (SVZ), which lines the ventricles (cavities) of the brain that contain cerebrospinal fluid, plays a role in reproductive function and possibly in maternal behaviors, although the function of "SVZ neurogenesis is obscure.
and neural stem cells of the central nervous system in mammals.
It was neither accidental nor incidental that it was a team of Canadian researchers working in a laboratory located in Canada, and not Muslim scientists working in a laboratory located in a Muslim country, that first presented scientific evidence of adult neurogenesis
, that is, the generation of new neurons in the hippocampus, allows the brain to react to new information flexibly.
Their topics include oxidative stress and its biochemical consequences in mitochondrial DNA mutation-associated diseases, caloric restriction and oxidative stress, oxidative stress in adult neurogenesis
and in the pathogenesis of Alzheimer Disease, cardiovascular diseases, anti-oxidant therapy and its effectiveness in oxidative stress-mediated disorders, endocrine control of oxidative stress in insects, molecular mechanisms of anti-oxidant protective processes in honeybee Apis mellifera, and effects of natural and anthropic stressors on oxidative challenges and redox sensing in mollusks.
Since the discovery of adult neurogenesis
in the mammalian brain (Altman and Das, 1965) and subsequent establishment of the fact that neuronal precursors actually exist in the adult (Reynolds and Weiss, 1992; Richards et al.
These factors, which are also dramatically down-regulated by amphetamine, can serve as valuable new entry points into studying the link between adult neurogenesis
and addiction," said the researchers.
The author describes the role of stem cells in regenerative therapy before discussing the latest research in adult neurogenesis
, stem cell engineering, BrdU immunohistochemistry and HuCNS-SC stem cells.
These are both very good papers and consistent with the growing appreciation for the importance of adult neurogenesis
in general and in particular in behavior," says Fred "Rusty" Gage, a neuroscientist at the Salk Institute for Biological Studies in La Jolla, Calif.