Adriamycin


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Related to Adriamycin: Taxol

Adriamycin

 [a″dre-ah-mi´sin]
trademark for preparations of doxorubicin, an antineoplastic antibiotic.

dox·o·ru·bi·cin

(doks'ō-rū'bi-sin),
An antineoplastic antibiotic isolated from Streptomyces peucetius; also used in cytogenetics to produce Q-type chromosome bands.
Synonym(s): adriamycin

Adriamycin

(ā′drē-ə-mī′sən)
A trademark for the drug doxorubicin.

Adriamycin

An anthracycline antibiotic with antineoplastic activity, which is used to treat haematologic malignancies, especially leukaemias, but also carcinomas and solid tumours (for which it is not particularly effective); its efficacy is hampered by cardiotoxicity that increases as the cumulative dose passes 500 mg/mm3.
Adverse effects Nausea, vomiting, neutropenia; about one-fourth of Adriamycin-treated patients develop late cardiac abnormalities once the cumulative dose passes 450 mg/mm2 including cardiac failure, dysrhythmia and sudden death; post-mortem examination of the heart reveals myocardial fibrosis.

adriamycin

Doxorubicin HCl Oncology An anthracycline antibiotic with antineoplastic activity, used to treat both leukemia and solid tumors; its efficacy is hampered by cardiotoxicity that ↑ as the cumulative dose passes 500 mg/mm3

Adriamycin

Doxorubicin. An anticancer drug which acts by interfering with cell division.
References in periodicals archive ?
Bakan, "Prevention of acute adriamycin cardiotoxicity by dantrolene in rats," Human & Experimental Toxicology, vol.
George, "Adriamycin in the treatment of childhood acute leukemia.
Adriamycin (doxorubicin hydrochloride, 99%, Solarbio, Beijing, China) was administered via a single intraperitoneal dose of 15 mg/kg in the ADM and ADM/Rg3 group.
Karayannacos, "Inhibition of adriamycin cardiotoxicity by 5-fluorouracil: a potential free oxygen radical scavenger," Anticancer Research, vol.
Rhabdomyosarcoma is treated by a combination of surgery, chemotherapy, and radiation, with the most frequently used chemotherapy agents being vincristine, cyclophosphamide, dactinomycin, adriamycin, ifosfamide, and virion protein VP-16 (etoposid).
Jenkins, "Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols," Cancer Research, vol.
The tumor size decreased after the initial course of chemotherapy (CYVADIC; cyclophosphamide 700mg/[m.sup.2], vincristine 2mg/[m.sup.2], adriamycin 70mg/[m.sup.2], dacarbazine (DTIC) 350mg x 4 days/[m.sup.2]); however, the tumor gradually increased in size over 6 courses of chemotherapy (Fig.
Fine et al., "Combination chemotherapy using adriamycin, DTIC, cyclophosphamide, and actinomycin D for advanced soft tissue sarcomas: a randomized comparative trial.
Only 6% of primary care physicians were able to identify the main long-term effects (LEs) of doxorubicin (Adriamycin), paclitaxel (Taxol), oxaliplatin (Eloxatin), and cyclophosphamide (Cytoxan), compared with 65% of oncologists surveyed.
After six cycles of VAD (vincristine, adriamycin, and dexamethasone) chemotherapy he obtained a good hematologic response.
The study also found that a regimen without the thug Adriamycin, an anthracycline commonly used to treat breast cancer but one that, especially when paired with Herceptin, can cause permanent heart damage, was comparable to a regimen with Adriamycin.