adrenocortical carcinoma

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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
.
References in periodicals archive ?
Targeting estrogen receptor-alpha reduces adrenocortical cancer (ACC) cell growth in vitro and in vivo: potential therapeutic role of selective estrogen receptor modulators (SERMs) for ACC treatment.
Infinity Pharmaceuticals announced that data to be presented today at the ASCO 2018 Annual Meeting demonstrates that IPI-549, a first-in-class immuno-oncology product candidate that selectively inhibits phosphoinositide-3-kinase gamma, in combination with nivolumab was well tolerated and demonstrated evidence of clinical activity in indications not typically responsive to anti-PD1 therapy 40% (12 of 30) of evaluable patients demonstrated disease control with 10 patients with stable disease and two patients who achieved rapid, deep and durable partial responses, including one patient with adrenocortical cancer and one with microsatellite stable gallbladder cancer.
The prognosis for cats with bilateral adrenal hyperplasia, despite the relative effectiveness of drug therapy, is not as good when compared to patients with adrenocortical cancer who underwent surgical treatment, which have better prognosis.
Piscitelli et al., "Rosiglitazone inhibits adrenocortical cancer cell proliferation by interfering with the IGF-IR intracellular signaling," PPAR Research, vol.
miR-195 and miR-483-5p identified as predictors of poor prognosis in adrenocortical cancer. Clin Cancer Res 2009; 15: 7684-7692, doi: 10.1158/10780432.CCR-09-1587.
Liposarcoma is extremely rare and is usually recognized as adrenocortical cancer because of its large volume.[sup.6] Liposarcoma often originates in retroperitoneal mesenchymal tissues, especially in the peri-renal area and is filled with lipoblast cells.
Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer. Eur Urol 2010;57:873-8.
One such event was the loss of Millie Schembechler, the wife of Bo Schembechler, to adrenocortical cancer in 1986.
The reduced-absent expression of VDR mRNA and protein in adrenocortical cancer may be caused by different molecular mechanism.
Adrenocortical cancer: Recent clinical and molecular advances.