adrenocortical carcinoma

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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
.
References in periodicals archive ?
Young (2003) reported adrenocortical cancer as part of a recognized syndrome in humans, known as multiple endocrine neoplasia (MEN), in which, in the presence of autosomal dominance, the patient develops tumors in endocrine organs, especially pancreas, thyroid, and pituitary.
The prognosis for cats with bilateral adrenal hyperplasia, despite the relative effectiveness of drug therapy, is not as good when compared to patients with adrenocortical cancer who underwent surgical treatment, which have better prognosis.
Rosiglitazone inhibits adrenocortical cancer cell proliferation by interfering with the IGF-IR intracellular signaling," PPAR Research, vol.
Liposarcoma is extremely rare and is usually recognized as adrenocortical cancer because of its large volume.
Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer.
One such event was the loss of Millie Schembechler, the wife of Bo Schembechler, to adrenocortical cancer in 1986.
Following a review of DCE-MRI data from 10 patients with N-cadherin positive tumors and 12 patients with N-cadherin negative tumors, the Company noted changes in Ktrans, a measure of blood flow to the tumor and other related parameters such as vascular permeability and interstitial tumor pressure, in three patients with N-cadherin positive tumors, including two with renal cancer and one with adrenocortical cancer, who also experienced the hormonal response described earlier.
The reduced-absent expression of VDR mRNA and protein in adrenocortical cancer may be caused by different molecular mechanism.
1[alpha],25-Dihydroxyvitamin D(3) inhibits the human H295R cell proliferation by cell cycle arrest: a model for a protective role of vitamin D receptor against adrenocortical cancer," Journal of Steroid Biochemistry and Molecular Biology, vol.
Targeting estrogen receptor-a reduces adrenocortical cancer (ACC) cell growth in vitro and in vivo: Potential therapeutic role of selective estrogen receptor modulators (SERMs) for ACC treatment," Journal of Clinical Endocrinology and Metabolism, vol.
Up to 79% of adrenocortical cancers produce some hormone or active agent that may lead to clinical symptoms.