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Combivent Inhalation Aerosol[R] is a combination of ipratropium (a long-acting, anticholinergic, bronchoconstrictor antagonist) and albuterol (a beta-2 adrenergic bronchodilator).
Adverse Effects of Beta-2 Adrenergic Agonist Inhalers
All beta-2 adrenergic agonist inhalers can stimulate immediate airway hyperactivity which leads to acute bronchospasm.
Limited research compares long-acting beta-2 adrenergic inhalers and their cardiovascular side effects.
To reduce blood pressure, beta blocker antihypertensive drugs are intended to inhibit specific, cardioselective, beta-1 adrenergic receptors in the heart and vascular walls.
Beta-2 adrenergic receptors are located in the smooth muscle of the bronchioles, blood vessels, genitourinary tract, uterus, gastrointestinal tract, liver, skeletal muscle, and pancreas.
Patients should not take other sympathomimetic drugs, monoamine oxidase (MAO) inhibitors, or tricyclic antidepressants while taking beta-2 adrenergic agonists.