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Pharmacodynamics: The alpha-2 adrenergic agonist activity (A2A) of desmedetomidine blocks the afferent activity of A and C fibers, associated with somato-sympathetic reflexes and spotaneous somatic flow, offering protection against stress.
Beta 2 adrenergic agonist drugs are widely used in obstetrics as tocolytics to inhibit or slow down labour and bronchodilators, but may act as functional and behavioural teratogens when given continuously in the mid to late second or early third trimesters.
Whether they are short-acting or long-acting, beta-2 adrenergic agonists can have cardiovascular side effects.
Bronchodilators like methylxanthines and beta adrenergic agonists are the two drugs most prominently used in the treatment of asthma.
2] adrenergic agonist are related to clonidine, acts as an analgesic, a sedative and as a sympatholytic with potent antinociceptive properties.
Dexmedetomidine is a highly selective [alpha]-2 adrenergic agonist with an affinity of eight times greater than that of clonidine.
The addition of adjuvants like alpha-2 adrenergic agonists, clonidine and dexmedetomidine can reduce the dose requirement and permit use of more diluted solutions for better analgesia and prevent the side-effects associated with larger volumes of local anesthetics.
Alpha 2 adrenergic agonists become popular because of their sedative, analgesic, antihypertensive, antiemetic actions in addition to reducing the anaesthetic drugs requirement.
Alpha-2 adrenergic agonists are being evaluated extensively as an alternative to neuraxial opioids, as an adjuvant.
16) Intrathecal injection of alpha 2 adrenergic agonists produces potent antinociceptive effects by altering spinal neurotransmitter release and effectively treats acute pain.