Adoptive Transfer


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Related to Adoptive Transfer: Flow cytometry, transgenic

Adoptive Immunotherapy

A form of passive immunisation in which sensitised cells or serum are transferred to an immunologically naive or lymphocyte-depleted recipient—e.g., for managing cancer, as in the use of IL-2/LAK cells.
About 10% of patients with terminal renal cell carcinoma and melanoma achieve partial or complete remission with LAK/IL-2; some response to LAK cells may occur in colorectal carcinoma and Hodgkin lymphoma; the effects may be dose-dependent, non-MHC-restricted, and require simultaneous high-dose IL-2.
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Jude also performed a pilot study in which 10 patients with AML in first complete remission (CR) not receiving HSCT (4 low risk, 6 intermediate risk) underwent haplo NK cell adoptive transfer after conditioning with cyclophosphamide and fludarabine [47].
To test this assumption, we performed adoptive transfers of effector [CD4.sup.+]CD62L T cells together with [CD11b.sup.+] bone marrow cells from HDC deficient or WT mice to NOD [RAG.sup.-/-]- recipients, which did not alter diabetes onset (Figure 2(d)), ruling out the increase of IMCs as a cause for diabetes progression.
To determine whether AhR activation during development changes [CD4.sup.+] T cells in an intrinsic or extrinsic fashion, we performed reciprocal adoptive transfer experiments.
HA-Vac (107 PFU) was delivered intraperitoneally (i.p.) in 0.1 mL HBSS as described [20] on day 15 after the adoptive transfer.
Even though 100% of our control NOD/scid mice developed diabetes with the mean onset of 6.5 weeks after adoptive transfer [12], in contrast, those treated with ATRA and ATRA plus exendin-4 developed diabetes with the mean onset of 8.0 and 11.2 weeks, respectively.
Adoptive transfer of Tregs reduces cardiac hypertrophy, inflammation, and fibrosis [28, 29], prevents Ang II-induced hypertension and vascular injury [15], and improves coronary arteriolar endothelial dysfunction in Ang II-hypertensive mice [30].
Induction of Tolerance by Adoptive Transfer of Treg Cells.
We conclude that accumulation is most likely due to pro longed cell survival, because adoptive transfer experiments demonstrated that C-Med 100 [R] treatment significantly prolonged lymphocyte survival in peripheral lymphoid organs, without increasing their proliferation rate.
A novel two-step process called adoptive transfer resulted in more than 50% tumor shrinkage in 6 of 13 patients with malignant melanoma, said Dr.
Adoptive transfer of splenic lymphocytes from immunized animals protected suckling mice against murine rotavirus-induced gastroenteritis in the absence of rotavirus-specific neutralizing antibodies, indicating that antigen-specific CTLs protect against mucosal pathogens in the intestinal tract (32).
These approaches have ranged from enhancing the proliferation of the cells following adoptive transfer via the expression of endogenous cytokines to suppression of tumor microenvironment (TME) inhibitory signals, or the enhancement of the cells' cytotoxic function.