AdoMet

AdoMet

Abbreviation for S-adenosyl-l-methionine.
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Brands: Adomet - Joint, Mood, Liver, Adogran - Joint, Mood, Liver, Adomix - Joint, Mood, Liver, Soloesse - Joint, Mood, Liver, Quatrefolic - Mood, Cellular Health, Prenatal & Lactation, Emothion - Liver, Cellular health, Vitamk7 - Bone, Cardiovascular health, Biootic - Gastrointestinal Health, Mythocondro - Joint, Phosphocomplex - Liver, Cellular health
S-adenosylmetheonine was for the first time discovered by Giulio Cantoni also known as AdoMet. It is conjugate of methionine and ATP.
Proteins including AdoMetDC, and AdoMet synthase were identified in alfalfa and their role were mentioned under drought and salt stresses (Bagga et al., 1997; Rahman et al., 2015).
The human enzyme is a 551-amino acid protein with a central catalytic domain, harboring a pyridoxal 5'-phosphate (PLP) cofactor, flanked by a C-terminal domain with a binding site for the allosteric positive regulator s-adenosyl-L-methionine (AdoMet) and an N-terminal domain, harboring a hexacoordinate heme with C52 and H65 as endogenous Fe ligands [11].
In the fall of 1973, I tested an idea that CPV transcriptase may require the methyl donor S-adenosyl-L-methionine (AdoMet), considering that methylation of mRNA might be a prerequisite for natural viral mRNA synthesis in infected silkworm cells.
Metabolism of methionine is essential to the optimal functioning of the cardiovascular, skeletal and nervous system in mammal and constitutes a methionine cycle with major intermediates of methionine (Met), S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy) and Homocysteine (Hcy).
It has been established that ethylene is biosynthesized from methionine via AdoMet and 1-aminocyclopropane-1-carboxylate (ACC) (Zeng et al., 2005).
Metabolism of levodopa (L-dopa) takes place in the brain and peripheral regions via the enzyme catechol-O-methyltrans-ferase (COMT) and requires S-adenosylmethionine (AdoMet) as a methyl donor for methylation reactions.
(June 1999), reported that "longterm treatment with ADoMet [SAM] may improve survival or delay liver transplantation in the patients with alcoholic liver cirrhosis, especially in those with less advanced liver disease." More recently, Chinese researchers reported: "SAM prevents alcohol-induced liver injury in rats by reducing liver lipid peroxidation, anti-inflammation, and antihyperplasia ...
However, in mammals on the other hand, are unable to synthesize homocysteine de novo; rather they use methionine synthase to regenerate methionine from homocysteine to provide one-carbon units for S-adenosyl-methionine (AdoMet)-dependent methylation reactions (Fig.
Por otra parte, se conoce que las poliaminas y el etileno tienen un intermediario comun en su ruta metabolica, la metionina, precursor directo de la AdoMet (S-adenosilmetionina) que es el donador metil primario en las reacciones de transmetilacion y participa en la biosintesis de ambos, poliaminas y etileno (Onouchi et al.
Terms: (A) ACC synthase (B) AdoMet (C) ACC oxidase (D) ACC