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Akne-Mycin, A/T/S, E-Glades, E-Solve 2, Erycette, Eryderm, Erygel, Sans-Acne (CA), Stiemycin (UK)
Pharmacologic class: Macrolide
Therapeutic class: Anti-infective
Pregnancy risk category B
Binds with 50S subunit of susceptible bacterial ribosomes, suppressing protein synthesis in bacterial cells and causing cell death
Capsules (delayed-release): 250 mg
Ointment (ophthalmic): 0.5%
Tablets: 250 mg, 500 mg
Tablets (delayed-release, enteric-coated): 250 mg, 333 mg, 500 mg
Tablets (particles in tablets): 333 mg, 500 mg
Oral suspension: 200 mg/5 ml, 400 mg/5 ml
Powder for suspension: 100 mg/2.5 ml, 200 mg/5 ml, 400 mg/5 ml Tablets: 400 mg
Powder for injection: 500 mg, 1 g
Tablets (film-coated): 250 mg, 500 mg
⊘Indications and dosages
➣ Pelvic inflammatory disease
Adults: 500 mg (base) I.V. q 6 hours for 3 days, then 250 mg (base, estolate, or stearate) or 400 mg (ethylsuccinate) q 6 hours for 7 days
Adults: 500 mg (base, estolate, or stearate) P.O. q.i.d. for 14 days
➣ Most upper and lower respiratory tract infections; otitis media; skin infections; Legionnaires' disease
Adults: 250 mg P.O. q 6 hours, or 333 mg P.O. q 8 hours, or 500 mg P.O. q 12 hours (base, estolate, or stearate); or 400 mg P.O. q 6 hours or 800 mg P.O. q 12 hours (ethylsuccinate); or 250 to 500 mg I.V. (up to 1 g) q 6 hours (gluceptate or lactobionate)
Children: 30 to 50 mg/kg/day (base, estolate, ethylsuccinate, or lactobionate) I.V. or P.O., in divided doses q 6 hours when giving I.V. and q 6 to 8 hours when giving P.O. Maximum dosage is 2 g/day for base or estolate, 3.2 g/day for ethylsuccinate, and 4 g/day for lactobionate.
➣ Intestinal amebiasis
Adults: 250 mg (base, estolate, or stearate) or 400 mg (ethylsuccinate) P.O. q 6 hours for 10 to 14 days
Children: 30 to 50 mg/kg/day (base, estolate, ethylsuccinate, or stearate) P.O. in divided doses over 10 to 14 days
➣ Prophylaxis of ophthalmia neonatorum caused by Neisseria gonorrhoeae or Chlamydia trachomatis
Neonates: 0.5- to 1-cm ribbon of ointment into each lower conjunctival sac once
➣ Treatment of conjunctivitis of the newborn caused by susceptible organisms
Neonates: 50 mg/kg/day (ethylsuccinate) P.O. in four divided doses for at least 14 days
Children: 40 to 50 mg/kg/day (estolate preferred) P.O. in four divided doses for 14 days
➣ Pneumonia of infancy
Infants: 50 mg/kg/day (estolate or ethylsuccinate) P.O. in four divided doses for at least 3 weeks
Adults and children older than age 12: 2% ointment, gel, or solution applied topically b.i.d.
topical/top·i·cal/ (top´ĭ-k'l) pertaining to a particular area, as a topical antiinfective applied to a certain area of the skin and affecting only the area to which it is applied.
topicaladjective Local, focal, superficial; referring to a body surface
topicalPertaining to something, usually medication, applied to a surface on or in the body, rather than taken internally or injected. Examples of topical applications are skin ointments or creams, eye and ear drops or ointments and vaginal pessaries.
2. of or pertaining to a drug or treatment applied to the surface of a part of the body.
Patient discussion about topical
Q. Your topic-manager: Did you have today a little crisis like me? As some of you already know, I use at the moment and since 3 months no medications anymore, but I told you also, that I have at home my little pharmacy for "just in case". Two days ago I slept not at all during the whole night. There was an emergency case from USA - a member from another topic. The dear lady was in panic, it seemed so during the chat. So I called her and she was thankful 12h later. Today I had a little panic-attack too. I have an urgent letter to write and also a document to prepare. In fact I would be able to do both things in the same time and so my body starts to feel a stress. My heart feels like a very hot big potato, my head is warm too and I can't concentrate me for just one subject. What have I done today to fix that?
Q. I need help with a delicate topic. My neice was diagnoised with Cranial Transannular Where he forehead was once as normal, now it has a forming point in the center to make it look as though her skull is shrinking inward. Please anyone help with any information you may have
Q. My son has atopic dermatitis that is treated with topical cream. Is he in a greater risk for other diseases? My 1 year old son has atopic dermatitis. We treat him with topical cream and he is getting better. What kind of a diseases is this? Is he in a greater risk for other diseases because of his skin lesions?