adipsin

Adipsin

A serine protease secreted by adipocytes into the circulation which is deficient in some animal models of obesity. It is identical to complement factor D.

adipsin

An enzyme secreted by fat cells, and also present in the Schwann cells of nerve fibres, that is thought to regulate fat metabolism. It acts on free lipoproteins and is concerned with fat oxidation. Its levels are markedly reduced in genetically obese mice. The full function of adipsin remains unclear.
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This study determined the levels of complement 3 (C3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue.
Among these many adipokines includes; adiponectin, leptin, resistin, visfatin, adipsin, apelin, cheperin and retinol binding protein-4 (RBP-4) [2,4].
These secretory proteins, which have been collectively named adipocytokines, include leptin, tumor necrosis factor (TNF)-[alfa], plasminogen-activator inhibitor type 1 (PAI-1), adipsin, resistin and adiponectin [5].
1993a) and; pioglitazone on cellular differentiation and expression of adipose-specific genes namely, adipsin and aP2, in 3T3-F44ZA cells have been reported.
Markers specific for adipocytes such as aP-2, adipsin, lipoprotein lipase and phosphoenolpyruvate carboxykinase appeared in G8 myoblasts co-expressing both C/EBP[alpha] and PPAR[gamma].
Genetic variation at the adipsin locus and response to long-term over-feeding.
But Spiegelman's team now reports finding that a much smaller excess of TNF-alpha depresses the expression of the genes responsible for producing the proteins adipsin and glut4.
Primary antibodies for aP2 and LPL (both from R&D Systems), adipsin (Santa Cruz Biotechnology), and [beta]-actin (13E5; Cell Signaling Technology), as well as appropriate horseradish peroxidase-labeled secondary antibodies were used.
adipsin, cathepsin S, leptin, adiponectin, chemerin, plasminogen activator inhibitor 1 (PAI-1), RBP-4, serum amyloid A1 (SAA-1), tissue inhibitor of metalloproteinase 1 (TIMP-1), and thrombopoietin.
After finding abnormal levels of a substance called adipsin in overweight rodents, researchers in Boston said last week that adipsin may be a contender for the adipostat title, as well as a marker to differentiate among obesities due to defects in genes, metabolism or just plain will power.
reported that treatment of 3T3L1 preadipocytes with 10 [micro]M bisphenol A [beta]-D-glucuronide (BPA-G) induced a significant increase in lipid accumulation, in mRNA expression of the adipogenic markers sterol regulatory element binding factor 1 (SREBF1) and lipoprotein lipase (LPL), and in protein levels of LPL, aP2, and adipsin.