The role of soluble adhesion molecules
and cytokines in sudden sensorineural hearing loss.
Intercellular adhesion molecule-1 (ICAM-1) serves as an adhesion molecule
which plays a crucial role in the cellular interactions involved in the immune responses as well as in the recruitment of cells.
Conclusion: Serum IL-4, IL-5, IL-10, adhesion molecules
and sE-selectin are all involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases.
L1 and epithelial cell adhesion molecules
associated with gastric cancer progression and prognosis in examination of specimens from 601 patients.
- Through research on the small molecule analogue of E6007 which is under clinical development as a treatment for inflammatory bowel disease (IBD)(1), a novel mechanism of action was revealed in which this analogue inhibited the adhesion and infiltration of various leukocytes through the blockade of the interaction between calreticulin (CRT)(2) and the leukocyte adhesion molecule
integrin(3) alpha (ITGA) by associating with CRT.
Novotny, "Soluble cell adhesion molecules
s-vcam-1 and s-icam-1 in subjects with familial combined hyperlipidemia," Biomedical Papers, vol.
Adhesion of inflammatory cells to vascular endothelium is mediated by cell adhesion molecules
, selectins and integrins .
These findings include the genes for several protein tyrosine phosphatase receptor type cell adhesion molecules
((PTPR); see http://www.genenames.org/cgi-bin/genefamilies/set/813 for a discussion of the nomenclature for this complex gene family), including PTPRD and PTPRB, as well as CUB and Sushi multiple domains 1 (CSMD1).
Arabzadeh, "Carcinoembryonic antigen-related cell adhesion molecules
(CEACAMs) in cancer progression and metastasis," Cancer Metastasis Reviews, vol.
Nitric oxide enables vasodilation, inhibits the proliferation, migration and differentiation of vascular smooth muscle cells to the intima of the blood vessel, stabilizes the inhibitory subunit of nuclear factor kappa B (NF-[kappa]B), that maintains this proinflammatory transcription factor in an inactive state, and thereby inhibits the expression of leukocyte adhesion molecules
, the production of chemokines and proinflammatory cytokines [6, 8].
Down syndrome cell adhesion molecule
(DSCAM) is located within the DSCR on chromosome 21q22.2-q22.3.
VSMCs then contribute to the growth of atherosclerotic lesions, due to their ability to proliferate and synthesize extracellular matrix and secrete adhesion molecules
that recruit and stabilize inflammatory cells, and might even take up lipids and contribute to foam cell formation .