cell adhesion molecule

(redirected from Adhesion molecule)
Also found in: Acronyms, Encyclopedia.

cell ad·he·sion mol·e·cule (CAM),

proteins that hold cells together, for example, uvomorulin, and hold them to their substrates, for example, laminin.
Farlex Partner Medical Dictionary © Farlex 2012

cell ad·he·sion mol·e·cule

(CAM) (sel ad-hē'zhŭn mol'ĕ-kyūl)
Proteins that hold cells together, e.g., uvomorulin, and hold them to their substrates, e.g., laminin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cell adhesion molecule



Any molecule that traverses the cell membrane and contains a chemical domain that binds it to other cells or to the extracellular matrix.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Serum Adhesion Molecule Levels in Acute Coronary Syndrome Among Indonesian Patients.
Abbreviations: HAECs, human aortic endothelial cells; TNF-[alpha], tumor necrosis factor-[alpha]; CAMs, cell adhesion molecules; sCAMs, soluble form of cell adhesion molecules; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1; PECAM-1, platelet endothelial cell adhesion molecule-1; sE-selectin, soluble E-selectin; sICAM-1, soluble ICAM-1; sVCAM-1, soluble VCAM-1; sPECAM-1, soluble PECAM-1; NF-[kappa]B, nuclear factor-[kappa]B; 1[kappa]B[alpha], inhibitor of NF-[kappa]B alpha; FITC-dextran, fluorescein isothiocyanate conjugated-dextran.
Lin et al., "SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms," Immunity, vol.
Wang et al., "Induction of heme oxy-genase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells," Journal of Agricultural and Food Chemistry, vol.
Adhesion molecules also have a role; Th1 cells express selectin ligands abundantly.
Chemokines are upregulated and increased expression of adhesion molecules is evident.
Similar results have been described in a previous study in endothelial cells, where they have reported that dehydroepiandrosterone (DHEA), an adrenal steroid abrogated expression of adhesion molecules in HUVEC, activated with either TNF-[alpha] or oxidized low density proteins [35].
Ito, "Circulating adhesion molecules and severity of coronary atherosclerosis," Coronary Artery Disease, vol.
Finally, endocan and soluble adhesion molecules were not examined in previous studies that focused on endothelial markers as prognostic parameters with regard to GVHD response to steroid treatment, and these authors did not detect any differences in pretransplant biomarkers between patients with or without later acute GVHD [35-37].
Thus, VAP-1 blockade reduced macrophage recruitment into CNV lesion indirectly via suppression of other adhesion molecules. Previous studies have demonstrated that marked suppression of VEGF is crucial for the suppression of CNV formation in the laser-induced CNV model [51,52].
Consequently, as the endothelium and inflammatory cells play a crucial role in the development of collaterals after a sudden or slowly progressing stenosis of coronary arteries, endothelial progenitor cells and soluble adhesion molecules determine the formation and the quality of the collaterals.