alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction
, resulting in cardiomyopathy and susceptibility to wall rupture.
Cytokines and adherens junctions
, E-cadherin and p120-catenin, change caused by high tidal volume mechanical ventilation in mice
Tight junctions and adherens junctions
form pericellular zipper
Johnson, "Inhibition of gap junction and adherens junction
assembly by connexin and A-CAM antibodies," The Journal of Cell Biology, vol.
Accumulating findings have shown that, with thrombin, TNF-[alpha], or endothelial growth factor (VEGF) treatments, stress fibers composed of actin and myosin play an important role in cell contraction and breaking down of the adherens junctions
Formation of both tight and adherens junctions
requires proper localization and assembly of ZO-1 scaffolding prior to recruitment of transmembrane proteins such as occludin or claudins .
(c) Colocalization of C4.4A (green) with the adherens junction
protein [beta]-catenin (red) in TES at day 28 of culture at the A/L interface.
These miRNAs were predicted to regulate pathways involved in obesity or in obesity-related cellular dysfunctions, the most significant being adipocytokine and PPAR signaling, some interrelated metabolic pathways (FoxO, cell cycle, MAPK, AMPK, p53, PI3K-Akt, TGFbeta signaling, and apoptosis), the cytoskeleton, and cell-cell adhesion (focal adhesion and tight and adherens junctions
VE-cadherin was found predominantly in the plasma membrane, as well as in the cytoplasm, forming nascent adherens junctions
at this early developmental stage (Figure 1(b)).
Dufton et al., "ZO-1 controls endothelial adherens junctions
, cell-cell tension, angiogenesis, and barrier formation," Journal of Cell Biology, vol.
(1-4) As a component of cell adherens junctions
, [beta]-catenin physically interacts with the cell membrane protein, E-cadherin, to stabilize the epithelial tissues.
All cells within both epithelia are joined by adherens junctions
that are stabilized by apical actin networks.