adherens junction

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adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture.
Cytokines and adherens junctions, E-cadherin and p120-catenin, change caused by high tidal volume mechanical ventilation in mice
Tight junctions and adherens junctions form pericellular zipper
Johnson, "Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies," The Journal of Cell Biology, vol.
Accumulating findings have shown that, with thrombin, TNF-[alpha], or endothelial growth factor (VEGF) treatments, stress fibers composed of actin and myosin play an important role in cell contraction and breaking down of the adherens junctions [48-50].
Formation of both tight and adherens junctions requires proper localization and assembly of ZO-1 scaffolding prior to recruitment of transmembrane proteins such as occludin or claudins [28].
(c) Colocalization of C4.4A (green) with the adherens junction protein [beta]-catenin (red) in TES at day 28 of culture at the A/L interface.
These miRNAs were predicted to regulate pathways involved in obesity or in obesity-related cellular dysfunctions, the most significant being adipocytokine and PPAR signaling, some interrelated metabolic pathways (FoxO, cell cycle, MAPK, AMPK, p53, PI3K-Akt, TGFbeta signaling, and apoptosis), the cytoskeleton, and cell-cell adhesion (focal adhesion and tight and adherens junctions).
VE-cadherin was found predominantly in the plasma membrane, as well as in the cytoplasm, forming nascent adherens junctions at this early developmental stage (Figure 1(b)).
(1-4) As a component of cell adherens junctions, [beta]-catenin physically interacts with the cell membrane protein, E-cadherin, to stabilize the epithelial tissues.
All cells within both epithelia are joined by adherens junctions that are stabilized by apical actin networks.