adherens junction


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adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
This study examined the relationship between inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-a, and IL-10) and adherens junctions (E-cadherin, p120-catenin), which were ameliorated by glutamine in VILI, both in vitro and in vivo.
The previous concept of BBB is a pure endothelial barrier of the brain, a physical barrier comprised of tight junctions (TJs) and adherens junctions (AJs) that limit paracellular diffusion of solutes between the blood and the brain [2, 3].
Our observations in monolayer culture of keratinocytes also fit this picture, with a clear membrane localization of C4.4A at cell-cell interaction points, suggesting a role of C4.4A in, for example, adherens junctions. In addition, the carbohydrate-binding lectin galectin-3, which has been implicated in cell-cell interactions and cell adhesion, has been identified as a ligand for C4.4A [48].
Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.
In the results of pathway analysis, "Adherens junctions" and "Focal adhesion" pathways were the two main types of junction that were modified by ISA adjuvants, which are known to mediate adhesion in epithelial cells (Yeatman, 2004).
[beta]- or [gamma]-catenin binds [alpha]-catenin to stabilize the adherens junction anchorage to the actin cytoskeleton.
Several junctional complexes, including adherens junctions and tight junctions, participate in this process [6].
Hammer et al., "Reduction and redistribution of gap and adherens junction proteins after ischemia and reperfusion," Annals of Thoracic Surgery, vol.
Stimulation of ICAM-1 leads to phosphorylation of VE-cadherin, which is a prerequisite for adherens junction disassembly.
Additionally, the tight junction and adherens junction pathways that play a role in the development of muscle contraction and structure were also regulated.