adherens junction


Also found in: Encyclopedia, Wikipedia.

adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.
Under these conditions, only the adherens junctions remain intact, and the epithelium with the adherens junction intact continues to impede the entrance of high molecular weight dextrans.
beta]- or [gamma]-catenin binds [alpha]-catenin to stabilize the adherens junction anchorage to the actin cytoskeleton.
Adherens junctions (AJs) are defined by the presence of cadherins (Takeichi, 1991), and are the major junctional type required for cell-cell adhesion across the Metazoa (Oda et al.
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: A review of recent data," Developmental Biology 286(1): 1-15.
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli--germ cell adherens junction dynamics in the testis," Journal of Cellular Physiology 202(1): 49-66.
QUESTION: Is the actin-mediated adherens junction disrupted by the presence of desmosomal cadherins that shouldn't be able to link up?
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis," Journal of Andrology 25(2): 200-215.
Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway," Biology of Reproduction 68(6): 2189-2206.
Adherens junctions and TJs play an important role for protecting the intestinal barrier.
beta]-catenin is the principal component of adherens junctions at cell-cell contact and is anchored to the cytoskeleton to support cellular architecture and organization of the cytoskeleton.
Using the Drosophila developing leg as a model system to study apoptosis-dependent epithelium folding, we have recently shown that apoptotic cells produce a pulling force through the unexpected maintenance of their adherens junctions that serves as an anchor to an apico-basal Myosin II cable.