Adenylosuccinase | definition of Adenylosuccinase by Medical dictionary
adenylosuccinate lyase (redirected from Adenylosuccinase)
ad·e·nyl·o·suc·ci·nate ly·ase (ad'e-nil-ō-sŭk'sin-āt lī'ās), [MIM*103050]
Adenylylsuccinate lyase; an enzyme catalyzing the nonhydrolytic cleavage of adenylosuccinic acid producing AMP and fumarate and also of 4-(N-succinocarboxamido)-5-aminoimidazole nucleotide to yield fumarate and aminoimidazole carboxamide ribosyl-5-phosphate. Both are steps in purine nucleotide biosynthesis.
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References in periodicals archive
Inborn errors of the purine nucleotide cycle: adenylosuccinase
The usefulness of this method was evaluated by analyzing urine samples from patients with established purine nucleoside phosphorylase deficiency, ornithine transcarbamylase deficiency, molybdenum cofactor deficiency, adenylosuccinase
deficiency, and dihydropyrimidine dehydrogenase deficiency.
Adenylosuccinate lyase, or adenylosuccinase
, catalyzes two reactions in the biosynthesis of purine nucleotides.