Construction of thymosin beta-4 recombinant adeno-associated virus
Xiao, "Rapid and highly efficient transduction by double-stranded adeno-associated virus
vectors in vitro and in vivo" Gene Therapy, vol.
He and his associates have focused on the relatively nonpathogenic adeno-associated virus
Protective effect of recombinant adeno-associated virus
2/8-mediated gene therapy from the maternal hyperphenylalaninemia in offsprings of a mouse model of phenylketonuria.
"There is a major difference between adeno-associated virus
vectors and adenovirus vectors,' he says.
A member of this family, the avian adeno-associated virus
(AAAV) has been fully characterized [3, 8] and successfully used for gene delivery in chicken embryo tissues and cells [7, 8].
In a phase II trial, researchers used an adeno-associated virus
to deliver the cystic fibrosis transmembrane conductance regulator gene to the lung epithelium.
Phase I trial results using an adeno-associated virus
that is injected into muscle to provide factor IX offer hope for patients with this disease.
Selecta Biosciences and Asklepios BioPharmaceutical announced a strategic partnership to jointly develop, manufacture and commercialize targeted therapeutics for life-changing, next-generation adeno-associated virus
gene therapies in areas of high medical need.
This product is an adeno-associated virus
vector-based gene therapy that targets the cause of SMA.
Currently, more than 130 companies in China are developing cell and gene therapies ranging from chimeric antigen receptor T cell therapy (CAR-T) / T cell receptor therapy (TCR-T) and adeno-associated virus
(AAV) to oncolytic virus.
Pall Corporation and Cell and Gene Therapy Catapult, will work with Cobra Biologics to investigate continuous manufacturing of adeno-associated virus
(AAV) for gene therapy applications.