Adeno-Associated Virus

(redirected from Adeno)

De·pen·do·vi·rus

(dē-pen'dō-vī'rŭs),
A genus of small defective single-stranded DNA viruses in the family Parvoviridae that depend on adenoviruses for replication.
[L. dependeo, to be dependent upon, + virus]

Adeno-Associated Virus

A member of the parvovirus family, which is composed of small viruses with a genome of a single-stranded DNA. AAVs insert genomic material at a specific site on human chromosome 19 with nearly 100% certainty, and are used to construct vectors that introduce genes into cultured cells. There is virtually no downside to AAV vectors, given the small amount of DNA they can carry and because AAV is non-pathogenic (most people are AAV carriers). In contrast to adenoviruses, AAV usually does not trigger an immune response to cells infected with it, and thus can deliver genes to sites of interest, including the brain in the context of gene therapy for diseases of muscle and eye, tissues where AAV seems to be most useful.
References in periodicals archive ?
lot number: 2: reagent package in immunology compartment (rota / adeno virus)
Epidermoid carcinoma in 64% of the patients (n=26), adeno carcinoma in 28% (n=11), and large cell carcinoma in 8% (n=3) were detected.
Large international differences in (adeno) tonsillectomy rates.
Results: The stress induced heart rate, systolic blood pressure and pulse pressure in adenoEx and adeno groups were 126.6 +- 19.0 vs 89.6 +- 15.2 p<.0001; 160.0 +- 20.4 vs 127.0 +- 21.2 p<.0001 and 75 +- 19.5 vs 50 +- 17.2 p<.0001 respectively.
BLOOD GROUP AND CARCINOMA OESOPHAGUS BLOOD GROUP NUMBER PERCENT B POSITIVE 39 31 A POSITIVE 36 29 O POSITIVE 34 27 AB POSITIVE 16 13 RH NEGATIVE 14 11.2 MIDDLE THIRD OESOPHAGUS CARCINOMA: 61 CASES Number Percent Well Differentiation Squamous cell 59 48.0 14 carcinoma Adeno 2 1 0 carcinoma Moderately Poorly Differentiation Differentiation Squamous cell 32 13 carcinoma Adeno 1 1 carcinoma LOWER THIRD OESOPHAGEAL CARCINOMA: 47 CASES NUMBER Percent Well differentiation Squamous cell 32 25.6 9 carcinoma Adeno 15 12.0 4 carcinoma Moderately Poorly differentiation differentiation Squamous cell 14 9 carcinoma Adeno 8 3 carcinoma The treatment modality offered approximately depends upon the site of the tumor, histopathology and cellular differentiation.
Therefore experiments have been performed to measure the antiviral activity of Sinupret[R] oral drops (hereinafter referred to as "oral drops") and Sinupret[R] dry extract (hereinafter referred to as "dry extract"), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/California/07/2009 (H1N1) virus (pFluA), parainfluenza type 3 virus (Para 3), respiratory syncytial virus, strain Long (RSV), human rhinovirus B subtype 14 (HRV 14), coxsackievirus subtype A9 (CA9), and adenovirus C subtype 5 (Adeno 5).
Attentuation of seizures and neuronal death by adeno associated virus vector galanin expression and secretion.
There was no evidence that screening had had any effect on the incidence or the mortality rate from adeno cancer which affects the glands around the cervix rather than the cervix wall itself.
The Histopathology report has come as Mucin secreting adeno carcinoma extending up to the serosa at the ileocecal junction.
Their topics include possible retrovirus vectors, adeno and adeno-associated virus vectors, gene therapy for acute renal failure due to ischemia-reperfusion issues and acute injuries, and treatment for chronically deteriorating renal function and renal fibrosis, and treatment for acute and chronic allograft rejection.
Avigen is a leader in the development of gene therapy products based on its AAV (adeno associated virus) delivery platform technology.