addressin


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ad·dres·sin

(ad-res'in),
A molecule on the surface of a cell that serves as a homing device to direct another molecule to a specific location.
[address, fr. O.Fr. adresser, to direct, fr. L.L. addirectiare, fr. L. ad, to, + directus, straight, direct, + -in]

addressin

A protein encoded by MADCAM1 on chromosome 19p13.3, which is a member of the immunoglobulin family and similar to ICAM1 and VCAM1. It is an endothelial cell-adhesion molecule which interacts preferentially with the leukocytes beta7 integrin LPAM-1, L-selectin and VLA-4 on myeloid cells, directing leukocytes into mucosal and inflamed tissues.

ad·dres·sin

(ă-dres'in)
A molecule on the surface of a cell that serves as a homing device to direct another molecule to a specific location.
[address, fr. O.Fr. adresser, to direct, fr. L.L. addirectiare, fr. L. ad, to, + directus, straight, direct, + -in]
References in periodicals archive ?
It is a humanized monoclonal antibody designed to specifically antagonize the 47 integrin, inhibiting the binding of 47 integrin to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1), but not vascular cell adhesion molecule 1 (VCAM-1)10.
Kelly Mary, 26, was eight months pregnant andfound with stab injuries at her addressin Raymead Avenue, Thornton Heath, Croydon, in the early hours of Saturday.
(15) It is a humanized monoclonal antibody designed to specifically antagonize the alpha4beta7 integrin, inhibiting the binding of alpha4beta7 integrin to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1), but not vascular cell adhesion molecule 1 (VCAM-1).
Liverpool Crown Court heard he wasbehind the management of an addressin Oak Street, Bootle, where 58 mature cannabis plants were discovered.
THATTA -- DIG Hyderabad rang Naeem Shiekh and told that suplying of narcotics particularly Gutka has played a havoc and bad trend in society by impacting on human health, he said police has started crackdown against it following the directives of IG sindh, this he said while addressin a press conference at SSP Thatta office here on Monday Appreciating the efforts of SSP Thatta Shabir Sathar in curbing the narcoticz uand other crimes in district Thatta, he directed the district police officers and cops to put an end of the narcotic.
Ang sinasabi ng Presidente, considering post-audit naman ang COA, hayaan na muna ang pangangailanagan ng taumbayan, saka na muna 'yang addressin 'yang mga napakaraming requirements ng COA,' Roque said in a press briefing in Benguet.
"So ang sinasabi ng Presidente, considering post-audit naman ang COA, hayaan na munang ibigay ang pangangailangan ng taumbayan, tsaka na muna addressin 'yang mga sinasabing nakapadaming requirements ng COA (So what the President is saying is since COA is post-audit, they should first give what the people need and let the local government address the many requirement afterward)," he added.
Jeffrey Birnie, 66, of Freelands Road, Cobham, wasarrested at an addressin the same road on Friday (August 31) after police responded to reports that ambulance staff had a pistol pulled on them.
One way to combat this is to exploit tissue specific addressin molecules, known to be present in both normal and disease tissues, as targets to deliver/concentrate drugs at the disease tissue site (Ferrari et al., 2016).
In order to validate the expression profiles observed in the gene expression profile, immunohistochemistry was pursued for chemokine (C-C motif) ligand 20 (CCL20), CCR6, mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1), and protocadherin gamma A3 (PCDHGA3), A8 (PCDHGA8), and B4 (PCDHGB4).
Preferential induction of peripheral lymph node addressin on high endothelial venulelike vessels in the active phase of ulcerative colitis.
Vedolizumab, a gut-selective immunosuppressive biologic, is a humanized monoclonal antibody that is designed to specifically antagonize the alpha4beta7 integrin, inhibiting binding to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and fibronectin, but not vascular cell adhesion molecule 1 (VCAM-1).