adapter protein

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adapter protein

An intracellular molecule that undergoes structural and functional changes in response to binding of cell membrane receptors by ligands. Adapter proteins participate in the immune response by acting as a bridge for enzymes in the signaling pathway needed to activate lymphocytes and initiate a response to an antigen.
See also: protein
References in periodicals archive ?
p66Shc, the 66Kd Shc protein, is an age-related adaptor protein that has a substantial impact on mitochondrial metabolism through regulation of cellular response to oxidative stress.
Signaling of TLR4 and TLR2 requires an additional adaptor protein MyD88-adapter-like (MAL) also known as TIRAP.
Adaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytes.
The ability of Nef to alter several cellular pathways by acting as an adaptor protein and a manipulator of protein trafficking, signal transduction and apoptotic pathways has been previously described.
The protein TRAF6 is a very important adaptor protein that is involved in multiple signaling pathways and its functions are important to maintain the stemness of satellite cells in adults," Kumar said.
Results from these studies on SVH-1, SVH-2 and SVH-3/FAAH-1 indicate that the activity of MLK-1 MAPKKK in promoting axon regeneration is regulated by at least two independent mechanisms: it is serine phosphorylated by TPA, which induces its kinase activity, and it is tyrosine phosphorylated by SVH-2, which promotes its interaction with the downstream target MEK-1 MAPKK via the adaptor protein SHC-1 (Fig.
Maslinic acid was shown to affect the expression of proteins involved in nucleotide metabolism, microtubule filament assembly, cytoskeleton organization, and adaptor proteins in the signal transduction pathway.
Ifso, CRP might then operate as a kind of fluid-phase adaptor protein, with each of its 2 faces capable of binding to their own unique ligand/receptor pair.
TLR4 trigger a common intracellular signalling pathway that includes myeloid differentiation factor 88 (MyD88) or Toll/IL-1 receptor domain-containing adaptor protein (TIRAP)/MyD88adaptor-like (MAL)16.
This leads to the recruitment, through the TIR, of adaptor proteins like the myeloid differentiation primary response protein 88 (MyD88), the Toll/IL-1 receptor domain containing adaptor protein (TIRAP), the Toll/ IL-1 receptor domain containing adaptor inducing interferon-beta (TRIF), and the TRIF-related adaptor molecule (TRAM) (Figure 2).
Death initiating signaling complex (DISC) is formed which contains an adaptor protein called FADD (Fas associated death domain) and procaspases-8.
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

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