adapter protein

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adapter protein

An intracellular molecule that undergoes structural and functional changes in response to binding of cell membrane receptors by ligands. Adapter proteins participate in the immune response by acting as a bridge for enzymes in the signaling pathway needed to activate lymphocytes and initiate a response to an antigen.
See also: protein
References in periodicals archive ?
AFAP is a small adaptor protein that can participate in intracellular signal transduction, cytoskeletal structure, and other cellular functions that directly activate c-Scr and induce its activity by modulating mechanical distraction.
Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer.
LC3 also enables the docking of specific cargos and adaptor proteins such as p62 (Sequestosome-1)(32).
Lei et al., "The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA," Immunity, vol.
Adaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytes.
TIRAP has been identified as a crucial adaptor protein in MYD88-dependent signaling pathway shared by TLR2 and TLR4.
Currently, little is known about the specific functions of OBSL1; yet, it was suggested that the OBSL1 protein functions as a cytoskeletal adaptor protein linking the nuclear proteins to the cytoplasmic support network.
Trejo, "Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins," The Journal of Biological Chemistry, vol.
Since no changes in MyD88 and TRIF adaptor protein expression were observed, it might have been assumed that TLRs did not contribute in NF-[kappa]B pathway activation by binase and RNase1.
The relocation of TJ-associated adaptor protein, ZO-1, to MDCK cell-cell contacts was indeed significantly accelerated in the presence of MSC.
Several Atg proteins are coordinated in this process termed cytoplasm-to-vacuole targeting; however, the Atg11 cytosolic adaptor protein is the physical link of the organelle to be degraded and the autophagosome in the case of both peroxisomes and mitochondria [175, 176].
Dab1 located in cytoplasm is an adaptor protein associated with neuronal migration and polarization [13].

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