adaptive immune system

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adaptive immune system

n.
The component of the vertebrate immune system involving lymphocytes (B cells and T cells) containing a small number of genetically encoded proteins that combine to produce an enormous variety of proteins capable of recognizing and deactivating specific antigens.
References in periodicals archive ?
Furthermore, Brucella pathogen has developed a battery of mechanisms to evade and/or modulate both innate and adaptive immune responses in their host.
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection.
Specific aspects of the adaptive immune response also are affected.
This new patent further validates the role of ResistAid larch arabinogalactan as an immune modulation ingredient, thanks to a wealth of validated science demonstrating its ability to selectively call upon both the non-specific, cellular response, as well as the adaptive immune response in healthy adults," said Bryan Rodriguez, global product manager for Lonza.
In the mouse experiment, similar damage to infected human hepatocytes was seen, which validates the theory that the adaptive immune response (T and B cells) was insignificant in the disease process.
The immune system has classically been divided into two compartments: (i) adaptive immune responses (T- and B-cells), which provide long-lived immunity to specific antigens, and are boosted through specific re-exposure to antigen, and (ii) innate immune responses (dendritic cells, phagocytes, natural killer cells), which are first to act upon exposure to a foreign antigen, and have been considered as 'nonspecific' and lacking the potential for memory of prior antigenic exposures (these features have been challenged by recent findings of NK cells in mouse models (13)).
In fact, the importance of the innate immune response and its relationship to the adaptive immune response was identified as the rationale for awarding all three Nobel prizes in medicine in 2011.
But some researchers believe HIV causes the innate immune system to overreact, thus weakening the adaptive immune response, the immune system's next line of defense.
This is important for activating the cells of the adaptive immune response.
During innate immune response process pathogens in the body are detected by phagocyte and antibodies are produced by the adaptive immune response to recognize specific pathogens.
Innate immunity has no specific memory but crucially activates the appropriate adaptive immune response that generates both lethal effector responses of exquisite specificity for, and long lived-cells with, memory for the insult.
According to this hypothesis, long-term exposure to tobacco smoke can induce the presentation of citrullinated autoantigens in the lungs in genetically predisposed persons, resulting in an activation of the adaptive immune response.

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