Pessin, "Interactions between Src homology (SH) 2/SH3 adapter proteins
and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor," Journal of Biological Chemistry, vol.
Functions of the adapter protein
Cas: signal convergence and the determination of cellular responses.
The inhibitory effects of Ser/Thr phosphorylation are implemented by different ways (Figure 1), including dissociation of IRS from the insulin receptor, converting it to an inhibitor of the receptor tyrosine kinase activity, attenuation of tyrosine phosphorylation of IRS, increased degradation of IRS, or releasing it from the complexes with the adapter proteins
Also the adapter proteins
FADD and NEMO appear to be crucial for TNF-alpha-induced necroptosis .
In the first section, contributors describe epidermal growth factor receptors (EGFRs) and their role in the ontology and maintenance of tumor tissues, detailing recent advances in the understanding of their molecular biology, including the intrinsic tyrosine kinase catalytic function and molecular interactions with other structures containing signaling adapter proteins
. They also detail research on anti- apoptotic mitogenic and metabolic signaling systems, signaling pathways, crosstalk between insulin and EGFRs, and the temporal dynamics of EGFR signaling in quantitative proteomics.