Nearly half of cholesterol molecules are transported to the endoplasmic reticulum (ER) after entering the epithelium and reesterified into CEs by Acyl-coenzyme A:cholesterol acyltransferases
Leung, "The structure and functions of human lysophosphatidic acid acyltransferases
," Frontiers in Bioscience, vol.
D126 hydrogen bonds with and stabilizes the position of H125 forming a catalytic dyad similar to that observed in other acyltransferases
Palmitoylation is catalyzed by a family of palmitoyl acyltransferases
(PATs) that contain a conserved DHHC (Asp-His-His-Cys) cysteine-rich domain directly involved in the palmitoyl-transfer reaction.
Coleman, "Glycerol-3-phosphate acyltransferases
: rate limiting enzymes of triacylglycerol biosynthesis," Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.
Urano, "Acylcoenzyme A: cholesterol acyltransferases
," American Journal of Physiology Endocrinology and Metabolism, vol.
Meanwhile, overexpression of diacylglycerol acyltransferases
(DGATs) has been shown to increase oil content in Arabidopsis (Jako et al., 2001) and soybean (Lardizabal et al., 2008).
Their topics include influences of maternal diet and exercise on obesity and insulin, alcohol and DNA methylation, the epigenetic regulation of cellular responses toward vitamin D, dietary effects on adipocyte metabolism and epigenetics, and the regulation of histone acyltransferases
and deacetylases by bioactive food compounds for the prevention of chronic diseases.
There is no significant sequence homology between PGAP2 and known acyltransferases
, and the issue of whether PGAP2 is the acyltransferase
itself or a regulatory protein remains to be determined.
In adipocytes, the biosynthesis of TAG is the result of esterification of alcoholic residues of G3P by various enzymes, namely, G3P acyltransferases
(GPATs, the most abundant isoforms being GPAT1 and GPAT2), 1acylglycerol-3-phosphate acyltransferase
(AGPAT, the most abundant isoform being AGPAT2), phosphatidic acid phosphatase, and diacylglycerol acyltransferase
(DGAT, the most abundant isoforms being DGAT1 and DGAT2).
Carnitine, acetylcarnitine and the activity of carnitine acyltransferases
in seminal plasma and spermatozoa of men, rams and rats.
Sightless has homology to transmembrane acyltransferases
and is required to generate active hedgehog protein.