acute phase protein

(redirected from Acute-phase reaction)
Also found in: Encyclopedia.

acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Serum concentrations of low molecular weight proteins are primarily determined by GFR, and an ideal marker should have a constant production rate and not vary in concentration during an acute-phase reaction. Cystatin C (13 kDa) and [beta]-trace protein (23-29 kDa) share these properties (1-3).
I conclude that the positive identification of previously described candidate serum biomarkers, BC2 and BC3, confirms my previous predictions that these are high-abundance proteins produced by the liver and that they represent nonspecific biomarkers of acute-phase reaction. Their performance as breast cancer biomarkers, as assessed by SELDI immunoassay, is not impressive and likely of questionable clinical value.
The presence of an acute-phase reaction was excluded by measurement of serum C-reactive protein.
It has been suggested that the SELDI-TOF MS technology has a preference toward detection of high-abundance protein molecules, such as acute-phase reaction proteins.
Thus, only a strong acute-phase reaction appears to trigger TATI expression.
Compared with bisphosphonates, denosumab also seems to cause fewer acute-phase reactions with flu-like symptoms.