acute phase protein

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acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
The production of PTX-3 is increased by the different proinflammatory cytokines [e.g., interleukin-1b, tumor necrosis factor-[alpha]], tissue damage or the stimulation of microbial agents.8,9 C-reactive protein (CRP) is an acute-phase protein that increases remarkably during infection, inflammation, and with tissue damage.
Because SAA is an acute-phase protein associated with amyloidosis, atherosclerosis, type 2 diabetes, and various malignancies, the differences in patients' baseline concentrations may affect their susceptibility to these diseases.
Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins.
Matzner, "Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states," Current Opinion in Hematology, vol.
This protein is known as an acute-phase protein that has immunomodulatory as well as anti-inflammatory effect and is also a marker for inflammatory diseases and endothelial injury [59-61].
The acute-phase protein response to infection in oedematous and nonoedematous protein-energy malnutrition.
CRP is an acute-phase protein produced by the liver.
(20.) Reid M, Badaloo A, Forrester T, Morlese JF, Heird WC, Jahoor E The acute-phase protein response to infection in edematous and nonedematous protein-energy malnutrition.
Fundamentally, an acute MI triggers a systemic response to a necrotic insult characterized by leukocytosis and acute-phase protein synthesis.
Classification of systemic amyloidosis AL (light-chain immunoglobulin) Plasma-cell/immunocyte dyscrasia Multiple myeloma AA (serum protein A) Acute-phase protein produced in response to inflammation Rheumatoid arthritis, inflammatory bowel disease, osteomyelitis, tuberculosis, familial Mediterranean fever Gastric carcinoma, renal cell carcinoma, Hodgkin's disease A[beta]2M ([[beta].sub.2] microglobulin) Chronic hemodialysis Familial AF (prealbumin protein) ATTR (transthyretin protein) Other rare familial types
Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6.
It becomes even more concentrated in the blood of chickens that are fighting infections, turning out to be a major acute-phase protein (APP).