acute phase protein

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acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins.
Virtually all of the abundant proteins in serum, with the exception of albumin, are A-linked glycoproteins, and the great majority of these are acute-phase proteins that rise or fall in response to acute and chronic inflammatory stimuli (2, 3).
Along with the deterioration of the immune response, PEM also modifies the acute-phase inflammatory response, in part, by alterations in the production and activity of inflammatory mediators, including cytokines and acute-phase proteins.
Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acute-phase protein response.
As a control group, sera were obtained from 47 randomly chosen, apparently healthy, young individuals (aged 17-46) and tested concurrently for each acute-phase protein.
1,3) During ongoing stimulation (chronic infection), positive acute-phase protein levels remain high compared with normal values and can be used for diagnostic purposes.
Serum amyloid A: an acute-phase protein involved in tumour pathogenesis.
Hp is a positive acute-phase protein and is characterized by molecular heterogeneity with 3 major phenotypes: Hp 1-1, Hp 2-2, and the heterozygous Hp 2-1 (3).
Among them, an acute-phase protein, SAA, was substantially increased in 44 sera from 24 SARS patients, in contrast to 72 sera from 51 control patients with different viral or bacterial infections.
Serum concentrations of C-reactive protein (CRP), [3] the classic acute-phase protein, cover a remarkable dynamic range and may exceed 500 mg/L at the peak of the acute-phase response (1).