acute tubular necrosis


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Related to acute tubular necrosis: Acute interstitial nephritis

necrosis

 [nĕ-kro´sis, ne-kro´sis] (Gr.)
the morphological changes indicative of cell death caused by enzymatic degradation.
aseptic necrosis necrosis without infection or inflammation.
acute tubular necrosis acute renal failure with mild to severe damage or necrosis of tubule cells, usually secondary to either nephrotoxicity, ischemia after major surgery, trauma (see crush syndrome), severe hypovolemia, sepsis, or burns. See also lower nephron nephrosis.
Balser's fatty necrosis gangrenous pancreatitis with omental bursitis and disseminated patches of necrosis of fatty tissues.
bridging necrosis septa of confluent necrosis bridging adjacent central veins of hepatic lobules and portal triads characteristic of subacute hepatic necrosis.
caseous necrosis caseation (def. 2).
central necrosis necrosis affecting the central portion of an affected bone, cell, or lobule of the liver.
cheesy necrosis caseation (def. 2).
coagulation necrosis death of cells, the protoplasm of the cells becoming fixed and opaque by coagulation of the protein elements, the cellular outline persisting for a long time.
colliquative necrosis liquefactive necrosis.
fat necrosis necrosis in which fat is broken down into fatty acids and glycerol, usually occurring in subcutaneous tissue as a result of trauma.
liquefactive necrosis necrosis in which the necrotic material becomes softened and liquefied.
massive hepatic necrosis massive, usually fatal, necrosis of the liver, a rare complication of viral hepatitis (fulminant hepatitis) that may also result from exposure to hepatotoxins or from drug hypersensitivity.
moist necrosis necrosis in which the dead tissue is wet and soft.
postpartum pituitary necrosis see postpartum pituitary necrosis.
selective myocardial cell necrosis myofibrillar degeneration.
subcutaneous fat necrosis of newborn a benign, self-limited disease affecting term newborns and young infants, characterized by circumscribed, indurated, nodular areas of fat necrosis. It is thought to be related to trauma on bony prominences during delivery, hypothermia, asphyxia, or maternal diabetes; it usually resolves spontaneously by 2 to 4 weeks with no scarring. Called also adiponecrosis neonatorum or subcutanea.
Zenker's necrosis hyaline degeneration and necrosis of striated muscle; called also Zenker's degeneration.

Acute Tubular Necrosis

A condition characterised by acute renal failure with oliguria, which returns to normal in days to weeks, with the caveat that 50% of patients die.
Aetiology Ischaemia—medical, obstetric, surgical, including transplantation (cold ischaemia); toxicity—drugs (aminoglycosides, amphotericin B, cyclosporine), chemicals (radiocontrast), pigments (myoglobin—crush syndrome, haemoglobinuria), sepsis, shock. Predisposing conditions Diabetes, liver disease, immunosuppression by toxic agents.
Management It is managed in transplanted kidneys in an expectant fashion as renal function may resume spontaneously in 2 to 4 weeks.

acute tubular necrosis

Nephrology A pathologic change of acute renal failure due to shock, crush injuries, hemoglobinuria, toxic nephrosis, sepsis, drugs-aminoglycosides, amphotericin B, cyclosporine, radiocontrast, ischemia in transplanted kidneys Predisposing conditions DM, liver disease; ATN in transplanted kidneys is managed in an expectant fashion as renal function may resume spontaneously in 2-4 wks

acute tubular necrosis

A severe kidney disorder featuring patchy damage to the fluid-reabsorbing tubules. Many of the lining cells of the tubules are destroyed and many of the tubules blocked. The condition may be due to inadequate blood supply or to various toxic effects including those of certain drugs such as the aminoglycoside antibiotics. There is a rapid decline in kidney function and patients usually require to be maintained on dialysis while recovery is taking place.
References in periodicals archive ?
Tran et al (26) concluded that renal failure in malaria results from acute tubular necrosis but not because of glomerulonephritis.
del Carmen Benitez et al., "Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation," PLoS One, vol.
One of the hallmarks of acute tubular necrosis is the loss of ability to concentrate urine.
The reason why ischemia did not result in acute tubular necrosis, delayed graft function in this patient is that this kidney had started diuresing postoperatively and later due to vascular kink ceased diuresing.
Paracetamol lacks peripheral prostaglandin inhibition, but may cause acute tubular necrosis in overdose.
Decreased ratio with decreased BUN may indicate acute tubular necrosis. Cystatin C Not affected by age, lean body mass, infection, or inflammation.
Renal artery thrombosis is a rare complication that can be caused by severe rejection, acute tubular necrosis or faulty surgical technique.
Acute tubular necrosis due to hypercalcemia secondary to vitamin D toxicity
(2) HELLP syndrome (haemolysis, elevated liver enzymes and low platelets) is a variant of severe pre-eclampsia which often complicates with renal failure, most of the time because of acute tubular necrosis (ATN) but occasionally because of RCN, through a thrombotic micro-angiopathic process.
Those dying between 2-3 weeks of illness presented interstitial edema and acute tubular necrosis (ATN) while those dying after three weeks of symptoms exhibited a diffuse and severe interstitial nephritis [17].
Prophylactic or therapeutic dosing with FG-4539 improved renal function as evidenced by lower BUN and serum creatinine levels, improved GFR, and prevented acute tubular necrosis as confirmed by histological analysis, the company said.
His hospital course was further complicated with multiorganism sepsis including multidrug-resistant pseudomonas, hepatic dysfunction, and renal failure caused by hemodynamically mediated acute tubular necrosis that required renal replacement.

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