Acute phase reactant

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Acute Phase Reactant

Any of a number of proteins that migrate in the alpha1 and alpha2 regions of a serum protein electrophoresis, which are elevated in acute inflammation. Acute phase reactants traditionally include alpha1-antitrypsin, alpha1 acid glycoprotein, amyloid A and P, anti-thrombin III, CRP, C1-esterase inhibitor, C3 complement, ceruloplasmin, fibrinogen, haptoglobin, orosomucoid, plasminogen, transferrin; reference ranges increase and the values themselves decrease with age. Acute phase reactants often have specific roles—e.g., acting as endogenous pyrogens or somnogens.


A chemical or substance taking part in a chemical reaction.

acute phase reactant

Acute phase protein.

limiting reactant

The substance with the lowest concentration in a chemical reaction. Its amount determines the amount of product made from that reaction.

Acute phase reactant

A substance in the blood that increases as a response to an acute conditions such as infection, injury, tissue destruction, some cancers, burns, surgery, or trauma.
References in periodicals archive ?
The acute phase response to tissue injury and inflammation is accompanied by a dramatic increase in the hepatic synthesis of plasma proteins known as acute phase reactants (APRs).
It is one of the most sensitive acute phase reactants, part of the response to endothelial injury due to ongoing inflammation.
In addition, visual analog scale-pain (VAS-pain), patient and physician global assessment, acute phase reactants (sedimentation and C-reactive protein) in blood samples were recorded.
This cytokine causes the de novo hepatic synthesis of acute phase reactants (12), and its concentration is increased in patients with unstable angina compared with those with stable angina (13).
Transferrin is described as an acute phase reactant protein.
Increased levels of fibrinogen, certain protein globulins, other acute phase reactants, and cholesterol may reduce the zeta potential, resulting in elevated ESR results.
In the current case, although wound-site infection was suspected initially because of the increased levels of acute phase reactants, further investigation revealed a pulmonary infection.
About Rheumatoid Arthritis Rheumatoid arthritis is a chronic inflammatory disease of unknown etiology in which patients exhibit sytemic features such as fatigue, low grade fever, weight loss, anemia and increased systemic levels of acute phase reactants (e.
Although colonization of these microorganisms could not be excluded, because of the persisting fever and high levels of acute phase reactants, these agents were accepted as pathogenic microorganisms.
The serum sodium levels were negatively correlated with acute phase reactants including leucocyte count (r=-0.
1) Moreover, other individual measures assessed by physicians also can be collected, such as joint count and acute phase reactants (e.
Markers of inflammation such as erythrocyte sedimentation rate (ESR) and acute phase reactants (APRs) such as C-reactive protein (CRP) and serum amyloid-A (SAA) are widely used for laboratory and clinical assessments of patients who have an inflammatory rheumatic diseases.

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