acute phase protein


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.
Farlex Partner Medical Dictionary © Farlex 2012

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
Medical Dictionary, © 2009 Farlex and Partners
Mentioned in ?
References in periodicals archive ?
Early biomarkers of inflammation in dogs and cats: The acute phase protein. Veterinary Research Communications, v.31, n.1, p.125-129, 2007a.
Acute phase proteins in cats/Proteinas de fase aguda em gatos
[sup][1] An increasing number of inflammatory markers and acute phase proteins have been tested in CAD, and their plasma levels have been confirmed to be correlated with different clinical characteristics and the prognosis of these patients.
Plasma a1-antitrypsin: A Neglected Predictor of Angiographic Severity in Patients with Stable Angina Pectoris
Nevertheless, elevation of both acute phase proteins was a poor prognostic sign and the results emphasize the importance of monitoring levels of these proteins on admission, during management and before discharge.
Acute phase proteins, C-reactive protein and serum amyloid A protein, as prognostic markers in the elderly inpatient
This phenomenon is known as the 'acute phase response'; one of its features is the production in the liver of 'acute phase proteins (APP)'.
COMPARATIVE STUDY OF CRP AND SERUM ALBUMIN AS STRESS RESPONSE MARKERS IN LAPAROSCOPIC VERSUS OPEN CHOLECYSTECTOMY
Vilcek, "TSG-14, a tumor necrosis factor-and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins," The Journal of Immunology, vol.
The Potential Role of Aerobic Exercise-Induced Pentraxin 3 on Obesity-Related Inflammation and Metabolic Dysregulation
Caption: Figure 3: Prohepcidin and acute phase protein levels during anti-TNF therapy in CD patients.
Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion
The acute phase protein serum amyloid A (SAA) as a marker of inflammation in horses.
Serum amyloid A as an indicator of health status in falcons
It can confirm an increase in IL-6 concentration corresponding with a little elevation of AGP concentration as acute phase protein. A 2-fold increase in the concentration of determined acute phase proteins (AAT and AGP) in the blood of AP patients was also demonstrated.
Resistin as a Prooxidant Factor and Predictor of Endothelium Damage in Patients with Mild Acute Pancreatitis Exposed to Tobacco Smoke Xenobiotics
In particular, a decrease in the prealbumin fraction may be an important early indicator; however, further investigations are necessary to identify the appropriate standardized methods to distinctively identify the electrophoretographic fractions and elucidate the significance of this potential negative acute phase protein in the diagnosis of aspergillosis in birds.
Serum protein electrophoresis by using high-resolution agarose gel in clinically healthy and Aspergillus species-infected falcons
Haptoglobin (Hp), a hemoglobin binding protein, is a representative acute phase protein (APP) in cattle, which is stimulated by inflammatory mediators and produced by liver.
Effects of fermented soybean meal on immune response of weaned calves with experimentally induced lipopolysaccharide challenge
The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells.
Quantification of fragments of human serum inter-[alpha]-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay
Serum Amyloid A is recognized as the most acute phase protein in horses and may increase by 10 to 100 times in inflammation, reaching values above 20,000ng [mL.sup.-1] (HINCHCLIFF et al., 2004; HOBO et al., 2007).
Post-ride inflammatory markers in endurance horses/Marcadores inflamatorios em cavalos apos enduro

Medical browser ?
Full browser ?