transplant rejection

(redirected from Acute organ rejection)

transplant rejection

Graft rejection, organ rejection, tissue rejection Immunology The constellation of host immune responses evoked when an allograft tissue is transplanted into a recipient; rejection phenomena may be minimized by optimal matching of MHC antigens and ABO blood groups and ameliorated with immunosuppressants–eg, cyclosporin, tacrolimus, rapamycin Exceptions of TR Corneal transplants, identical twins. See Graft-versus-host disease, HLA, MHC, Tissue typing.


1. an organ or tissue taken from the body and grafted into another area of the same individual or another individual.
2. to transfer tissue from one part to another or from one individual to another.

ovum transplant
see ovum transplant.
transplant rejection
References in periodicals archive ?
8]] in combination with basiliximab, results in significantly better renal function and a lower incidence of acute organ rejection when compared with standard dose ADVAGRAF therapy.
While prevention of acute organ rejection is a key priority for physicians following liver transplantation, managing other health risks, including impaired renal function associated with calcineurin inhibitor treatment, is also critical," said John Fung, M.
Biomarkers in Transplantation, a research initiative that will allow doctors to identify patients rejecting transplanted organs with a simple blood test, is making use of advanced genomic, proteomic, and computational tools to develop the test, which will diagnose rejection before acute organ rejection occurs, allowing doctors to intervene early and to personalize a patient's immunosuppressant therapy.
CellCept was first approved for use in combination therapy for the prevention of acute organ rejection in kidney transplantation in 1995 and has since been approved worldwide for prevention of organ rejection in adult kidney, heart and liver transplantation.
MADRID -- OTC supplements can stimulate the immune system and trigger acute organ rejection in transplant recipients, as seen in a series of five cases at one hospital.
Rapamune is indicated for the prevention of acute organ rejection in kidney transplant patients and is recommended to be used in a regimen that includes cyclosporine and corticosteroids.
where the study was performed, has halted preoperative administration of OKT3, reserving it instead as a last resort for patients who show signs of acute organ rejection.
This trial is concerned with the prevention of acute organ rejection and chronic graft injury (allograft nephropathy) and will be conducted at the University of Cairo.
In the 45 years since the first successful human heart transplant, concerns about short-term or acute organ rejection have largely been addressed by drugs like cyclosporine.
SYDNEY, Australia, October 25 /PRNewswire/ -- A study published today in the journal Circulation shows that sirolimus used from the time of heart transplantation, provides sustained protection against coronary allograft vasculopathy whilst also halving acute organ rejection in these patients.
Rapamune was approved by the FDA in September 1999 for use in combination with cyclosporine and corticosteroids for the prevention of acute organ rejection in kidney transplant patients.
Food and Drug Administration (FDA) for its Phase 3 clinical trial comparing TOL101 to Thymoglobulin, the current market leading induction agent, for prevention of acute organ rejection.

Full browser ?