activin

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ac·tiv·in

(ak'ti-vin),
Placental hormone that reaches maximum levels in maternal serum during labor; helps to regulate production of gonadotropin-releasing hormones, human chorionic gonadotropin, and steroids by the placenta.
[active + -in]

activin

/ac·ti·vin/ (ak´tĭ-vin) a nonsteroidal regulator synthesized in the pituitary glands and gonads that stimulates the secretion of follicle-stimulating hormone.

activin

(ăk′tə-vĭn, ăk-tĭv′ĭn)
n.
A polypeptide growth factor that is synthesized in the pituitary gland and the gonads and stimulates the secretion of follicle-stimulating hormone.

Activin

Either of two dimeric proteins belonging to the TGF-beta superfamily (as do inhibin and bone morphogenic protein) which act primarily through SMADs, a class of signal transducers, which are involved in DNA-binding and signal transduction. Activins are involved in all stages of the cell cycle: proliferation, differentiation, metabolism, homeostasis, and death (apoptosis), as well as immune response and tissue repair—activins A and B are highly expressed during wound repair and healing, and have yin-yang relationship with inhibin. Activins are involved in differentiation of erythroid precursors and erythroleukemia cell lines, neuronal survival, stimulation of insulin and anterior pituitary hormone secretion, regulation of the menstrual cycle, increasing FSH production and granulosa cell differentiation by binding to follistatin, an FSH release inhibitor.

ac·tiv·in

(ak'ti-vin)
Placental hormone that reaches maximum levels in maternal serum during labor.

activin

a gonadal peptide hormone isolated from follicular fluid; has an unidentified role in stimulating FSH secretion.
References in periodicals archive ?
Earlier studies in mammals, in which direct binding assays of soluble ActRII and ActRIIB to radiolabeled activins and inhibins were tested, revealed that both receptors bind activin A with high affinity (del Re et al.
Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators.
2005 Activins, inhibins and follistatins in the large domestic species.
Therefore, we considered activin A as a positional candidate affecting litter size and evaluated their sequence for potential causative genetic variation.
Methods covered in the patents describe the use of activin and serum-free culture conditions for producing endoderm and mesoderm.
Methods utilizing differing concentrations of activin to direct and control the differentiation of various mature cell types are described in these issued U.
Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin.
Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.
It has been difficult to design assays that distinguish Inhibin A from other, structurally similar transforming growth factor-[beta] superfamily proteins, particularly the free a subunits, Inhibin B and activin A.
Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-R signaling in anterior pituitary cells.
DSL's strength in the field of reproductive endocrinology combined with OBI's focus and experience in the area of Inhibins and Activins will enable us to accelerate the development of additional products and clinical applications in this field," Savjani added.
Based in Oxford, England, OBI was founded in 1998 and is a leader in the development, manufacture and marketing of diagnostic and research products for the measurement of Inhibin and Activin levels.