activin

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ac·tiv·in

(ak'ti-vin),
Placental hormone that reaches maximum levels in maternal serum during labor; helps to regulate production of gonadotropin-releasing hormones, human chorionic gonadotropin, and steroids by the placenta.
[active + -in]
Farlex Partner Medical Dictionary © Farlex 2012

activin

(ăk′tə-vĭn, ăk-tĭv′ĭn)
n.
A polypeptide growth factor that is synthesized in the pituitary gland and the gonads and stimulates the secretion of follicle-stimulating hormone.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Activin

Either of two dimeric proteins belonging to the TGF-beta superfamily (as do inhibin and bone morphogenic protein) which act primarily through SMADs, a class of signal transducers, which are involved in DNA-binding and signal transduction. Activins are involved in all stages of the cell cycle: proliferation, differentiation, metabolism, homeostasis, and death (apoptosis), as well as immune response and tissue repair—activins A and B are highly expressed during wound repair and healing, and have yin-yang relationship with inhibin. Activins are involved in differentiation of erythroid precursors and erythroleukemia cell lines, neuronal survival, stimulation of insulin and anterior pituitary hormone secretion, regulation of the menstrual cycle, increasing FSH production and granulosa cell differentiation by binding to follistatin, an FSH release inhibitor.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ac·tiv·in

(ak'ti-vin)
Placental hormone that reaches maximum levels in maternal serum during labor.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
"In nature, we knew that Activin A and follistatin work in opposite ways to regulate cells," says Doetzlhofer.
has dosed the first patient in a Phase 1 study evaluating investigational agent TP-0184, an activin A receptor type 1 (ACVR1) inhibitor, in patients with advanced solid tumors, the company said.
In the next series of experiments to improve ES R1 cell differentiation, human Activin A (100 ng/ml, Invitrogen), human BMP4 (100 ng/ml, Sigma), PD98059 (50 [micro]M, Sigma), and LY294002 (25 [micro]M, Sigma) were added together with RA from day 5 to day 10.
Activin A and B are also members of the TGF-[beta] superfamily, and have a variety of actions in both embryonic and adult tissues, including tissue fate determination in vertebrate embryos, regulation of follicle-stimulating hormone biosynthesis in pituitary gonadotrophs, and regulation of gametogenesis in ovaries and testes (Welt et al., 2002).
They discovered an activin A increase in the blood and fat tissue of the aged mice.
4- hiPSCs were incubated for 3 days with RPMI-1640 medium (Gibco, USA) containing 100 ng/ml Activin A (R&D, USA), 1.0% B27 (Gibco, USA) and insulin-transferrin-selenite (ITS, Gibco, USA).
Bovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro.
In the present study, we evaluated the patterns of activin A and follistatin expression in the livers of obese rats subjected to swimming exercise.
Patella et al., "Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia," Proceedings of the National Academy of Sciences of the United States of America, vol.
Although there is no evidence that proves the direct involvement of activins on the upregulation of proinflammatory cytokines and chemokines induced by TLR signals, we consider that it is likely because previous studies reported that activin A release after LPS exposure was significantly suppressed in mice lacking MyD88 and that follistatin significantly inhibited the surge of serums TNF[alpha], IL1[beta], and IL6 after LPS challenge in mice [17].
Oxidant damage triggers a molecule called Activin A to go to work, the researchers reported last year in Breast Cancer Research.
Recombinant human activin A was purchased from R&D Systems (Minneapolis, MN, USA) and 15-deoxy-[[DELTA].sup.12, 14]- prostaglandin [J.sub.2] was obtained from Cayman Chemical (Ann Arbor, MI, USA).

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