activin

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ac·tiv·in

(ak'ti-vin),
Placental hormone that reaches maximum levels in maternal serum during labor; helps to regulate production of gonadotropin-releasing hormones, human chorionic gonadotropin, and steroids by the placenta.
[active + -in]

activin

/ac·ti·vin/ (ak´tĭ-vin) a nonsteroidal regulator synthesized in the pituitary glands and gonads that stimulates the secretion of follicle-stimulating hormone.

activin

(ăk′tə-vĭn, ăk-tĭv′ĭn)
n.
A polypeptide growth factor that is synthesized in the pituitary gland and the gonads and stimulates the secretion of follicle-stimulating hormone.

Activin

Either of two dimeric proteins belonging to the TGF-beta superfamily (as do inhibin and bone morphogenic protein) which act primarily through SMADs, a class of signal transducers, which are involved in DNA-binding and signal transduction. Activins are involved in all stages of the cell cycle: proliferation, differentiation, metabolism, homeostasis, and death (apoptosis), as well as immune response and tissue repair—activins A and B are highly expressed during wound repair and healing, and have yin-yang relationship with inhibin. Activins are involved in differentiation of erythroid precursors and erythroleukemia cell lines, neuronal survival, stimulation of insulin and anterior pituitary hormone secretion, regulation of the menstrual cycle, increasing FSH production and granulosa cell differentiation by binding to follistatin, an FSH release inhibitor.

ac·tiv·in

(ak'ti-vin)
Placental hormone that reaches maximum levels in maternal serum during labor.

activin

a gonadal peptide hormone isolated from follicular fluid; has an unidentified role in stimulating FSH secretion.
References in periodicals archive ?
Activin A and B are also members of the TGF-[beta] superfamily, and have a variety of actions in both embryonic and adult tissues, including tissue fate determination in vertebrate embryos, regulation of follicle-stimulating hormone biosynthesis in pituitary gonadotrophs, and regulation of gametogenesis in ovaries and testes (Welt et al.
They discovered an activin A increase in the blood and fat tissue of the aged mice.
In an existing study (5), it has been indicated that hiPSCs could be efficiently differentiated into the endoderm cells through EBs formation in the differentiation media, including Activin A, ITS and B27 supplements using hMSCs feeder.
Bovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro.
This led us to believe that activin A must have some systemic function when overproduced in a cancer setting," Nature quoted Han as saying.
Hershey College of Medicine, and colleagues analyzed pretreatment levels of serum activin A in 60 metastatic breast cancer patients prior to initiation of first-line trastuzumab-containing therapy.
Heparinized samples of blood taken at 4 time points [before surgery (time 0), during surgery before CPB (time 1), at the end of CPB (time 2), at the end of surgery (time 3), and 12 h after surgery (time 4)] were assayed for activin A.
Activin A was measured at first urination (time 0, mean collection time 1 h), 12 (time 1), 24 (time 2), 48 (time 3), and 72 (time 4) h of age.
Activin A measurements were performed blinded and in duplicate with a specific 2-site enzyme immunoassay from Serotec (12).
On admission, all patients were checked against routine clinical and laboratory values, and CSF samples were obtained by lumbar puncture for routine examination and activin A assessment in the first 24-h after birth.
It has been difficult to design assays that distinguish Inhibin A from other, structurally similar transforming growth factor-[beta] superfamily proteins, particularly the free a subunits, Inhibin B and activin A.

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