fos

(redirected from Activator protein 1)
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Related to Activator protein 1: Activator Protein 2

FOS

A gene on chromosome 14q24.3 that encodes a leucine zipper DNA-binding FOS-type nuclear phosphoprotein, which dimerises with proteins of the JUN family to form the transcription factor complex AP1. FOS proteins regulate cell proliferation, differentiation and transformation, and may be associated with apoptosis.

fos

(fas)

A family of cancer-causing genes, first identified in viruses, that function within cells as transcription factors. Members of this family can transform normal cells (e.g., fibroblasts) into cancer cells (e.g., osteosarcomas, chondrosarcomas). See: oncogene; transformation

Etiology

The name is derived from “FBJ osteosarcoma virus, ” in which these oncogenes were first identified.

References in periodicals archive ?

Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.

Inhibition of activator protein 1 activity and neoplastic transformation by aspirin.

Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

AP-1, NF[kappa]B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. (Articles)

9) The activator protein 1 family of proteins consists of the Fos (cFos, Fos-B, Fos-related antigen 1 [FRA-1], and FRA-2) and Jun (c-Jun, Jun B, and Jun D) subfamilies.

Expression of FRA-1 was also studied, because FRA-1 belongs to the activator protein 1 family of transcription factors and members of this family are known to interact with NF-[kappa]B.

Increased levels of nuclear factor [kappa]B and Fos-related antigen 1 in lung tissues from patients with acute respiratory distress syndrome