activated prothrombin complex concentrate

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Related to activated prothrombin complex concentrate: FEIBA, Kcentra

concentrate

[kon´sen-trāt]

1. to bring to a common center; to gather at one point.

2. to increase the strength by diminishing the bulk of, as of a liquid; to condense.

3. a drug or other preparation that has been strengthened by evaporation of its nonactive parts.

activated prothrombin complex concentrate (APCC) anti-inhibitor coagulant complex.

prothrombin complex concentrate (PCC) factor IX complex.

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References in periodicals archive ?

Perzborn, Potential of activated prothrombin complex concentrate and activated factor VII to reverse the anticoagulant effects of rivaroxaban in primates, Practice., 2, 3 (2008).

Reversal Agents for Oral Anticoagulant Rivaroxaban

Sequential therapy with activated prothrombin complex concentrates and recombinant FVIIa in patients with severe haemophilia and inhibitors: update of our previous experience.

Terapia secuencia!; una opcion en el paciente hemofilico que no responde a! manejo con monoterapia con agentes puente, estudio observaciona! de! GrHeCol (Grupo Hemofilia Colombia)

Treatment options are similar to those of acquired haemophilia A and include the following approaches: 1) control of bleeding, mostly achieved using a bypassing agent such as recombinant factor VIIa or activated prothrombin complex concentrate, even though FFP and PLT transfusion can be used; 2) eradicate the inhibitor by introducing immunosuppression with steroids and cytotoxic agents (recently anti-CD20 monoclonal antibodies have been used with encouraging results, especially in cases of acquired haemophilia A and; 3) the use of IV immunoglobulin, which remains controversial (2,5,6,9).

Successful Outcome of Severe Intra-cerebral Bleeding Associated with Acquired Factor V Inhibition: Utilization of Multiple Therapeutic Agents