Part 1: Validation of whole-blood heparin concentration and activated clotting time
. Perfusion 2003; 18:269-276.
ACT: Activated clotting time
: These are usually done at the bedside.
The rTEG test incorporates both tissue factor and kaolin to generate the conventional kaolin parameters, as well as the TEG activated clotting time
(ACT) parameter, which is measured in seconds.
ACT (activated clotting time
) had been done after induction of anesthesia, 10 minutes after giving heparin, on CPB, and after administration of protamine.
Activated clotting time
(ACT): This test is similar to the aPTT, and depends on factors that constitute the intrinsic pathway of coagulation.
Efficacy in this study was measured by ACT (Activated Clotting Time
), a standard bedside measurement.
The activated clotting time
was measured simultaneously on all six channels.
Indeed, several previous studies have demonstrated that activated clotting time
values are known to be very method dependent (5, 7-10).
Systemic heparinization was maintained and activated clotting time
fluctuated between 180 and 200 s.
(2,3) In order to prevent activation of the hemostatic system into the circuit, unfractionated heparin (UH) is usually administered for patients on ECMO and therapeutic anticoagulation is monitored by various laboratory tests: activated clotting time
, activated partial thromboplastin time (aPTT), anti-Xa assay, and thromboelastography.
The manufacturer of argatroban recommends monitoring patients undergoing percutaneous coronary intervention, or PCI, using activated clotting time
(ACT) with a therapeutic goal of 300 seconds to 450 seconds.