actinic keratosis

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keratosis

 [ker″ah-to´sis]
any horny growth, such as a wart or callosity.
actinic keratosis a sharply outlined wartlike or keratotic growth, which may develop into a cutaneous horn, and may become malignant; it usually occurs in the middle aged or elderly and is due to excessive exposure to the sun. Called also senile or solar keratosis. (See Atlas 3, Part F).
keratosis follicula´ris a slowly progressive autosomal dominant disorder of keratinization characterized by pinkish to tan or skin-colored papules on the seborrheic areas of the body that coalesce to form plaques, which may become crusted and secondarily infected; over time, the lesions may become darker and may fuse to form papillomatous and warty malodorous growths. Called also Darier's disease and Darier-White disease.
keratosis palma´ris et planta´ris palmoplantar keratoderma.
keratosis pharyn´gea horny projections from the tonsils and pharyngeal walls. Called also pharyngokeratosis.
keratosis pila´ris hyperkeratosis limited to the hair follicles.
keratosis puncta´ta a hereditary hyperkeratosis in which the lesions are localized in multiple points on the palms and soles.
seborrheic keratosis (keratosis seborrhe´ica) a benign, noninvasive tumor of epidermal origin, marked by numerous yellow or brown, sharply marginated, oval, raised lesions.
senile keratosis (solar keratosis) actinic keratosis.

ac·tin·ic ker·a·to·sis

a premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned persons; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients.

actinic keratosis

A premalignant lesion of sun-exposed skin that is overly sensitive to the effects of UV light (i.e., sunlight), and more common in the fair-skinned or elderly, and the immunocompromised.
 
Diagnosis
Biopsy.
 
Management
Cryosurgery, photodynamic therapy, laser (CO2, Er:YAG), electrocautery; some topical immune response modifiers (e.g., 5FU) may be used to promote peeling.
 
Prognosis
± 20% of AKs develop into squamous cell carcinoma.

Prevention
Broad-spectrum sunscreens with a sun protection factor of 17 may reduce new lesions; avoid photosensitising drugs (e.g., tetracyclines); in subjects with AK placed on a low-fat diet, the incidence of new lesions fell to 1⁄3 that of the control (non-diet intervention) group. HPV replication is thought to play a role in malignant changes.

actinic keratosis

Senile keratosis, solar keratosis Dermatology A premalignant lesion of sun-exposed skin that is overly sensitive to the effects of UV light–sunlight, and more common in the fair-skinned or elderly Clinical Discrete scaly or gritty erythematous plaques located on a sun exposed surface Diagnosis Biopsy Management Cryosurgery or electrocautery; some topicals may be used to promote peeling Prognosis ± 20% of AKs develop into SCC Prevention Broad-spectrum sunscreens with a sun protection factor of 17 may ↓ new lesions; avoid photosensitizing drugs–eg, tetracyclines. See Squamous cell carcinoma.

ac·tin·ic ker·a·to·sis

(ak-tin'ik ker'ă-tō'sis)
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned people; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients. Treatment includes cryotherapy, surgical excision, or topical chemotherapy.
Enlarge picture
ACTINIC KERATOSIS: Actinic skin damage on forehead and scalp

actinic keratosis

Abbreviation: AK
A rough, sandpaper-textured, premalignant macule or papule caused by excess exposure to ultraviolet light. AKs often appear on facial skin (such as near the eyes, on the nose, on the ears, or the lips) and the parts of the body that receive the most sunlight exposure. Prevention of AKs depends on limiting one's exposure to sunlight, beginning in childhood and continuing throughout life. See: illustration

Treatment

Liquid nitrogen destroys these lesions and prevents them from progressing to other cancers of the skin.

Synonym: solar keratosis See: sunscreen
See also: keratosis

actinic keratosis

Local overgrowth and thickening of the EPIDERMIS of the skin caused by sunlight. This condition can progress to a form of skin cancer (SQUAMOUS CELL CARCINOMA) and is usually treated by freezing.

Actinic keratosis

A crusty, scaly pre-cancerous skin lesion caused by damage from the sun. Frequently treated with cryotherapy.

ac·tin·ic ker·a·to·sis

(ak-tin'ik ker'ă-tō'sis)
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned people.
References in periodicals archive ?
Lynn Cornelius (left) conducts a skin exam with patient Robert Manchester, a participant in the clinical trial evaluating the calcipotriol-5-FU combination as a treatment for actinic keratoses.
As in previous studies, the number of actinic keratoses also declined in the nicotinamide group.
The FDA nod is based on data from four Phase III trials in over 1000 patients treated with ingenol mebutate (n=503) or placebo (n=502) demonstrating that ingenol mebutate applied once-daily for two or three consecutive days is significantly more effecient than placebo at clearing actinic keratoses.
The research team, led by University of Alabama at Birmingham senior scientist Craig Elmets, evaluated the efficacy and safety of celecoxib as a chemo-preventive agent for actinic keratoses.
There are two important things to consider with actinic keratoses. Firstly, some will progress to a form of skin cancer.
The study demonstrated that actinic keratoses (AKs) are common precursors not only to squamous cell carcinoma (SCC) but also to basal cell carcinoma (BCC), contrary to conventional wisdom, Dr.
Reliability of counting actinic keratoses before and after brief consensus discussion: the VA topical tretinoin chemoprevention (VATFC) trial.
These include vascular lesions, leg veins, pigmented lesions and tattoos, laser treatments for scars, treatment of actinic keratoses and nonmelanoma skin cancer, acne, and psoriasis.
Around 96 per cent have never heard of actinic keratoses and almost half would ask a friend or relative to look at a mark on their skin rather than a health professional.