actinic keratosis

(redirected from Actinic Keratosis.)
Also found in: Dictionary, Thesaurus.
Related to Actinic Keratosis.: actinic cheilitis

keratosis

 [ker″ah-to´sis]
any horny growth, such as a wart or callosity.
actinic keratosis a sharply outlined wartlike or keratotic growth, which may develop into a cutaneous horn, and may become malignant; it usually occurs in the middle aged or elderly and is due to excessive exposure to the sun. Called also senile or solar keratosis. (See Atlas 3, Part F).
keratosis follicula´ris a slowly progressive autosomal dominant disorder of keratinization characterized by pinkish to tan or skin-colored papules on the seborrheic areas of the body that coalesce to form plaques, which may become crusted and secondarily infected; over time, the lesions may become darker and may fuse to form papillomatous and warty malodorous growths. Called also Darier's disease and Darier-White disease.
keratosis palma´ris et planta´ris palmoplantar keratoderma.
keratosis pharyn´gea horny projections from the tonsils and pharyngeal walls. Called also pharyngokeratosis.
keratosis pila´ris hyperkeratosis limited to the hair follicles.
keratosis puncta´ta a hereditary hyperkeratosis in which the lesions are localized in multiple points on the palms and soles.
seborrheic keratosis (keratosis seborrhe´ica) a benign, noninvasive tumor of epidermal origin, marked by numerous yellow or brown, sharply marginated, oval, raised lesions.
senile keratosis (solar keratosis) actinic keratosis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ac·tin·ic ker·a·to·sis

a premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned persons; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients.
Farlex Partner Medical Dictionary © Farlex 2012

actinic keratosis

A premalignant lesion of sun-exposed skin that is overly sensitive to the effects of UV light (i.e., sunlight), and more common in the fair-skinned or elderly, and the immunocompromised.
 
Diagnosis
Biopsy.
 
Management
Cryosurgery, photodynamic therapy, laser (CO2, Er:YAG), electrocautery; some topical immune response modifiers (e.g., 5FU) may be used to promote peeling.
 
Prognosis
± 20% of AKs develop into squamous cell carcinoma.

Prevention
Broad-spectrum sunscreens with a sun protection factor of 17 may reduce new lesions; avoid photosensitising drugs (e.g., tetracyclines); in subjects with AK placed on a low-fat diet, the incidence of new lesions fell to 1⁄3 that of the control (non-diet intervention) group. HPV replication is thought to play a role in malignant changes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

actinic keratosis

Senile keratosis, solar keratosis Dermatology A premalignant lesion of sun-exposed skin that is overly sensitive to the effects of UV light–sunlight, and more common in the fair-skinned or elderly Clinical Discrete scaly or gritty erythematous plaques located on a sun exposed surface Diagnosis Biopsy Management Cryosurgery or electrocautery; some topicals may be used to promote peeling Prognosis ± 20% of AKs develop into SCC Prevention Broad-spectrum sunscreens with a sun protection factor of 17 may ↓ new lesions; avoid photosensitizing drugs–eg, tetracyclines. See Squamous cell carcinoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ac·tin·ic ker·a·to·sis

(ak-tin'ik ker'ă-tō'sis)
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned people; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients. Treatment includes cryotherapy, surgical excision, or topical chemotherapy.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Enlarge picture
ACTINIC KERATOSIS: Actinic skin damage on forehead and scalp

actinic keratosis

Abbreviation: AK
A rough, sandpaper-textured, premalignant macule or papule caused by excess exposure to ultraviolet light. AKs often appear on facial skin (such as near the eyes, on the nose, on the ears, or the lips) and the parts of the body that receive the most sunlight exposure. Prevention of AKs depends on limiting one's exposure to sunlight, beginning in childhood and continuing throughout life. See: illustration

Treatment

Liquid nitrogen destroys these lesions and prevents them from progressing to other cancers of the skin.

Synonym: solar keratosis See: sunscreen
See also: keratosis
Medical Dictionary, © 2009 Farlex and Partners

actinic keratosis

Local overgrowth and thickening of the EPIDERMIS of the skin caused by sunlight. This condition can progress to a form of skin cancer (SQUAMOUS CELL CARCINOMA) and is usually treated by freezing.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Actinic keratosis

A crusty, scaly pre-cancerous skin lesion caused by damage from the sun. Frequently treated with cryotherapy.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

ac·tin·ic ker·a·to·sis

(ak-tin'ik ker'ă-tō'sis)
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned people.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
This manufacturer-sponsored study evaluated the efficacy and safety of 5% imiquimod (Aldara) cream for the treatment of actinic keratosis.
22 September 2011 - German dermatology drugs company Biofrontera AG (FRA:B8F) said today it had submitted as planned the documents for processing the last open issues related to the new drug application to the European Medicines Agency (EMA) for BF-200 ALA, its medicinal product for the treatment of actinic keratosis.
29 September 2010 - German pharmaceutical company Biofrontera AG (FRA: B8F) said today that the European Medical Agency (EMA) has confirmed the successful validation of the drug approval dossier for BF-200 ALA for the treatment of actinic keratosis.
BF-200 ALA gel is a drug for the treatment of actinic keratosis. It is applied in the relatively novel photodynamic therapy (PDT).
According to the company, the Picato Gel (ingenol mebutate) 0.05% is indicated for the topical treatment of actinic keratosis.
6 January 2010 - German dermatology drugs maker Biofrontera AG (FRA: B8F) said it received detailed results confirming the superiority of its drug candidate BF-200 ALA in a Phase III comparative trial with Metvix for the treatment of actinic keratosis.
The company is currently researching creams for nail fungus, dry and scaly skin, anal fissures, and actinic keratosis.
The case concerns the extension of the US patent covering Photocure's drug Metvixia, approved by the US Food and Drug Administration (FDA) for treatment of actinic keratosis. In September 2004, Photocure submitted an application for patent term extension but the patent office refused it.