Denny, "Acridine derivatives as chemotherapeutic agents," Current Medicinal Chemistry, vol.
Antonini, "DNA-binding antitumor agents: From pyrimido[5,6,1-de]acridines to other intriguing classes of acridine derivatives," Current Medicinal Chemistry, vol.
As a consequence, they have been extensively used in anti-parasitic chemotherapy and a wide range of new numerous acridines derivatives have been synthesized and successfully assessed for their anti-leishmanial properties [1, 14].
The purpose of the present study was to perform quantitative structure-activity relationship (QSAR) determinations of a series of sixteen compounds based on (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone (shown Figure 1) that have been synthesized and evaluated for their toxicity towards monocytes [IC.sub.50] (concentration of acridine compounds responsible for a 50% decrease of monocyte growth), as demonstrated by Florence Delmas et al.
As mentioned in 3.2, the main nitrogen compounds in the feedstock are nitriles, anilines, pyridines, quinolines, acridines, indoles and carbazoles.
nitriles > anilines > pyridines > quinolines > acridines > indoles > carbazoles
Albert, The Acridines, Edward Arnold Publications, London, UK, 1966.
Structureactivity relationships for acridine monosubstituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9aminoacridine-4-carboxamide," Journal of Medicinal Chemistry, vol.
The first group, spanning clades A to F, mostly comprises members of the Gomphocerinae; the single exception, clade E, consists of a melange of acridines
This behavior indicated that although different substitution on benzene ring increases the zone of inhibition but no overall effect on the antimicrobial activity which may be originated by the hydrazides group incorporated with main acridine
Duplex DNA, on the other hand, prefers the acridine
conjugate with the longest linker length, and RNA has the highest affinity for the conjugate with an intermediate linker length.
Keywords: Cynarasaponins; Euglena gracilis; Ofloxacin; Acridine