Acquired von Willebrand Disease


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Acquired von Willebrand Disease

A misnomer for a coagulopathy (it is not a disease per se) caused by an acquired defect in von Willebrand factor secondary to malignancy, lupus, or drugs—e.g., ciprofloxacin, valproic acid, etc.
References in periodicals archive ?
Acquired von Willebrand disease (AvWD) is a rare bleeding disorder [1, 2].
Michiels et al., "Acquired von Willebrand disease caused by an autoantibody selectively inhibiting the binding of von Willebrand factor to collagen," Blood, vol.
Also, Heyde syndrome is characterized by calcific aortic stenosis, acquired von Willebrand disease, and angiodysplasia in colon and caecum causing gastrointestinal haemorrhage.3 So, prothrombin time, active partial thromboplastin time, von Willebrand Factor level should be evaluated in these patients.