aconitate hydratase

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ac·on·i·tate hy·dra·tase

(ă-kon'i-tāt hī'dra-tās),
An iron-containing enzyme catalyzing the dehydration of citrate to cis-aconitate, a reaction of significance in the tricarboxylic acid cycle.
Synonym(s): aconitase
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References in periodicals archive ?
We performed BLAST searches of our ND2 and aconitase sequences against the GenBank nucleotide database to identify candidate parent species with high percent sequence identity.
Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.
After binding ISC [4Fe-4S], IRP1 functions as aconitase, and loses its IRE-related functions.
Nitric oxide modulates the activity of tobacco aconitase.
Mitochondrial aconitase is the enzyme responsible for the isomerization of citrate to isocitrate in the tricarboxylic acid (TCA) cycle.
The goal of this study was to examine the influence of exercise training and type I diabetes on the activity of aconitase and superoxide dismutase (SOD), on levels of reduced glutathione (GSH), on the expression of genes responsible for glutathione synthesis (Gclc, g-glutamylcysteine synthase; Gss, glutathione synthetase), and on the expression of genes responsible for the formation of two potassium channels (Kcnd2, [I.
Nitric oxide combines with reactive oxygen to create "an entire soup of bacteriocidal intermediates" in a wound, and poisons the iron enzyme aconitase.
In animal models, Aconitase activity has been found to decline relative to age and disease state.
Fluorocitrate binds irreversibly to the enzyme aconitase, thereby stopping the citric acid cycle, which stops the production of the essential cellular energy molecule ATP.
2009), we noted no changes of inflammatory and prethrombosis biomarkers in the heart, but we observed inhibition of myocardial mitochondrial aconitase activity and suppression of compensatory genes; therefore, we postulated that ozone and DEP exposure might cause cardiac mitochondrial membrane PUFA to be altered because of oxidative stress.
We sequenced the Z-linked nuclear intron Aconitase intron 9, using primers AcolIOF and Acoll0R2 (|F.