aconitate hydratase

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ac·on·i·tate hy·dra·tase

(ă-kon'i-tāt hī'dra-tās),
An iron-containing enzyme catalyzing the dehydration of citrate to cis-aconitate, a reaction of significance in the tricarboxylic acid cycle.
Synonym(s): aconitase
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References in periodicals archive ?
Superoxide radical and iron modulate aconitase activity in mammalian cells.
ATX antagonized ischemia-mediated loss of aconitase activity and reduced glutamate release, lipid peroxidation, translocation of cytochrome c, and TUNEL labeling in the ischemic cortex.
To assess mitochondrial oxidant load, we quantified aconitase activity from mitochondrial isolates [see Supplemental Material, page 7 (doi:10.
2 Converts Fe+1 to (TSAP6) Fe+2 in endosomes IRP1 100880 1RP1 9p22-pl3 Bifunctional (ACOl) protein, acts as aconitase or iron response protein due to cellular iron levels IRP2 147582 IRP2 15q25.
Thus NO inhibits tobacco aconitase and iron-sulphur-containing enzyme that catalyzes the isomerisation of citrate to isocitrate (Navarre et al.
STRUCTURAL STUDIES OF HUMAN MITOCHONDRIAL ACONITASE.
The IRP1 was soon recognized as counterpart of mitochondrial aconitase due to its ability to assemble a [Fe-4S] cluster (48).
The goal of this study was to examine the influence of exercise training and type I diabetes on the activity of aconitase and superoxide dismutase (SOD), on levels of reduced glutathione (GSH), on the expression of genes responsible for glutathione synthesis (Gclc, g-glutamylcysteine synthase; Gss, glutathione synthetase), and on the expression of genes responsible for the formation of two potassium channels (Kcnd2, [I.
We used buffer system 8, as modified by Haufler (1985), to resolve phosphoglucoisomerase (PGI) and triosephosphate isomerase (TPI) ; and system 9 to resolve aconitase (ACN), fructose-l,6-diphosphatase (F16DP), phosphoglucomutase (PGM) and shikimate dehydrogenase (SKDH).