KLK15

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KLK15

A gene on chromosome 19q13.3-q13.4 that encodes a serine  endopeptidase with a trypsin- and chymotrypsin-like substrate specificity, which may: activate/inactivate proteinase-activated receptors F2R, F2RL1 and F2RL3, as well as other kallikreins (e.g., KLK1, KLK3, KLK5 and KLK11); liquefy seminal clot by cleaving semenogelins SEMG1 and SEMG2 and activating KLK3; cleave desmoglein DSG1, resulting in shedding of superficial keratinocytes from the skin surface; and play a role in tumour progression by affecting growth, invasion and angiogenesis.
References in periodicals archive ?
This index also included a measure of the change in summed scores, if any, between 2011 and 2012, to monitor possible changes in ACO performance.
In new metrics captured by the 2017 ACO survey, one-third of responding ACOs include behavioral health providers, and 26 percent of responding ACOs cover more than 100,000 lives.
It was fascinating to thoroughly read a new analysis from the Commonwealth Fund, which, as this publication reported recently, examined the results of a Commonwealth Fund-supported study published in the October issue of Health Affairs and authored by researchers from Harvard University, the University of California-Berkeley, Dartmouth College, and elsewhere, which looked at data from national surveys of 399 accountable care organizations (ACOs), examining differences between the 228 commercial ACOs studied, and the 171 non-commercial (Medicare or Medicaid) ACOs studied.
The agency noted that another 83 ACOs in the Shared Savings Program and two Pioneer ACOs generated savings in 2015 but did not qualify for bonus payments.
MEASUREMENT IS NOT ENOUGH--Under the current models, Centers for Medicare and Medicaid Services (CMS) provides ACOs with a number of different types of data from which to derive quality and cost performance metrics: paid health care claims, ACO benchmark data, beneficiary demographics, chronic conditions (HCC scores) and attribution.
The agency said that a Medicare ACO could be tax-exempt because it moves forward "the charitable purpose of lessening the burdens of government.
the president and CEO at Geisinger, presented a model for ACO implementation in 2011 that heavily influenced the CMS approach.
Q: We have seen mixed reports regarding the adoption of technology by ACO groups.
One of the results of that effort is the ACO concept.
The Centers for Medicare & Medicaid Services launched the Pioneer ACOs in 2012 to control cost increases tied to a standard fee-for-service system that tends to favor better-compensated services.
Manama Municipality Director underscored Bahrain's municipalities' keenness to benefit from ACO organized meetings and training workshops.
The next few months will be busy as the ACO physicians focus on extracting and evaluating the data to better understand their patients and their individual needs.