KLK15

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KLK15

A gene on chromosome 19q13.3-q13.4 that encodes a serine  endopeptidase with a trypsin- and chymotrypsin-like substrate specificity, which may: activate/inactivate proteinase-activated receptors F2R, F2RL1 and F2RL3, as well as other kallikreins (e.g., KLK1, KLK3, KLK5 and KLK11); liquefy seminal clot by cleaving semenogelins SEMG1 and SEMG2 and activating KLK3; cleave desmoglein DSG1, resulting in shedding of superficial keratinocytes from the skin surface; and play a role in tumour progression by affecting growth, invasion and angiogenesis.
References in periodicals archive ?
Singh, "Ant Colony Optimization (ACO) based Routing Protocols for Wireless Sensor Networks (WSN): A Survey," International Journal of Advanced Computer Science & Applications, 2017.
The agency noted that another 83 ACOs in the Shared Savings Program and two Pioneer ACOs generated savings in 2015 but did not qualify for bonus payments.
In addition to these data, providers within the ACO contribute HCAHPS survey data and potentially clinical data from electronic health record systems.
The agency said that a Medicare ACO could be tax-exempt because it moves forward "the charitable purpose of lessening the burdens of government."
He notes that shared savings models have shown some success, but primarily, "they provide the opportunity to test a variety of models, and they have encouraged a range of provider systems to embark on the ACO path, ranging from those that are the most well-developed and able to take on greater accountability to those that are just getting started."
For ACOs participating in the Medicare Shared Savings program, improvement was shown in 27 of 33 quality measures, including patients' ratings of clinicians' communication, patients' ratings of their doctors, screening for tobacco use and cessation, screening for high blood pressure, and EHR use.
An ACO is any value-driven organization that has cared enough to take a look inward and assess their business, rather than simply responding to external requirements and stimulus that have traditionally come from payers.
CMS officials have announced the change in a set of Medicare Shared Savings Program ACO final regulations that's set to appear in the Federal Register Tuesday.
Performance for Pioneer ACO populations was shown to be better in terms of patient-reported timely care and clinician communication, the investigators found.
In terms of structure and operations, all ACOs are different, Nimsky said, noting there are insurance company-driven and employer-driven ACOs, such as a recent announcement by Boeing to begin working directly with ACOs with no insurance company involved.
The ACO receives contracting authority from the DCMA headquarters or a designated official through the issuance of a Standard Form 1402, Certificate of Appointment, also known as a warrant.