zoledronate

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zoledronate

Zoledronic acid, Zometa® Osteoporosis A potent bisphosphonate used to ↓ fractures, ↓ bone pain Indications Postmenopausal osteoporosis, CA metastases to bone Adverse events Myalgia, pyrexia. See Biphosphonate, Osteoporosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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The study has shown that Aclasta (zoledronic acid), traded as Reclast in the USA, preserved bone mass in post-menopausal osteoporotic patients who were given annual infusions of the product for six years.
A rare thigh bone injury occurred in patients treated with the so-called bisphosphonates, which include Aclasta and Roche's Boniva.
Wall Street sees its key growth drivers (Diovan, Tekturna, Gleevec, Tasigna, Exjade and Aclasta) as the company's "cliff protection"--when branded drugs go off patent and face competition from generics.
For example, Tasigna, a new cancer drug, and Aclasta, a once-yearly infusion for women with osteoporosis, have been submitted for regulatory approval in both the United States and Europe.
Meanwhile research suggests once-a-year drug Aclasta cuts deaths among osteoporosis sufferers.
The drug, zoledronic acid (Aclasta) has been tested on almost 8,000 women and showed a 70 per cent reduction in fractures of vertebrae of the spine, and a 41 per cent reduction in hip fractures.