Aciphex


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Related to Aciphex: Prevacid, Rabeprazole, Nexium, Zantac, Pariet

rabeprazole sodium

AcipHex, Novo-Rabeprazole (CA), Pariet (UK), PMS-Rabeprazole (CA), Ran-Rabeprazole (CA)

Pharmacologic class: Proton pump inhibitor

Therapeutic class: Gastric antisecretory agent

Pregnancy risk category B

Action

Reduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating a protective coating on gastric mucosa

Availability

Tablets (delayed-release): 20 mg

Indications and dosages

Erosive or ulcerative gastroesophageal reflux disease (GERD)

Adults: 20 mg P.O. daily for 4 to 8 weeks. If healing doesn't occur within 8 weeks, another 8 weeks of therapy may be considered. Maintenance dosage is 20 mg P.O. daily.

GERD

Adults: 20 mg P.O. daily for 4 weeks. If symptoms don't resolve after 4 weeks, another course of therapy may be considered.

Short-term treatment of symptomatic GERD

Adolescents ages 12 and older: 20 mg P.O. daily for up to 8 weeks

Hypersecretory conditions, including Zollinger-Ellison syndrome

Adults: Initially, 60 mg P.O. daily; adjust dosage as needed up to 100 mg P.O. daily as a single dose or 60 mg P.O. b.i.d. Maximum daily dosage is 120 mg.

Duodenal ulcer

Adults: 20 mg P.O. daily for up to 4 weeks

Helicobacter pylori eradication

Adults: 20 mg P.O. b.i.d. for 7 days (given with amoxicillin and clarithromycin)

Off-label uses

• Dyspepsia
• Benign gastric ulcer

Contraindications

• Hypersensitivity to drug, its components, or benzimidazoles

Precautions

Use cautiously in:
• severe hepatic impairment
• concurrent use of atazanavir (not recommended)
• pregnant patients
• breastfeeding patients (not recommended)
• children (safety not established).

Administration

• Don't crush or split tablets.
• Give without regard to food.

Adverse reactions

CNS: headache

Metabolic: hypomagnesemia

Musculoskeletal: fractures of hip, wrist, spine (with long-term daily use)

Interactions

Drug-drug.Atazanavir: substantially decreased atazanavir plasma concentration and reduced therapeutic effect Combined administration of rabeprazole, amoxicillin, and clarithromycin: increased rabeprazole and 14-hydroxyclarithromycin plasma concentrations

Gastric pH-dependent drugs (such as digoxin, ketoconazole): increased or decreased absorption

Methotrexate: possibly elevated and prolonged methotrexate serum level

Warfarin: increased risk of bleeding

Drug-diagnostic tests.Magnesium: decreased level

Patient monitoring

• Stay alert for symptomatic response, but know that a positive response doesn't rule out gastric cancer.
• Monitor magnesium level before starting therapy and periodically thereafter in patients expected to be on prolonged therapy or who take proton pump inhibitors with drugs such as digoxin or drugs that may cause hypomagnesemia (such as diuretics).

Patient teaching

• Tell patient he may take with or without food. Instruct him not to crush, chew, or split tablets.
• Caution female patient not to breastfeed during therapy.
• As appropriate, review all significant adverse reactions and interactions, especially those related to the drugs mentioned above.

Aciphex

(ăs′ĭp-hĕks′)
A trademark for the drug rabeprazole sodium.

Aciphex®

An oral proton pump inhibitor used to manage erosive or ulcerated gastrooesophageal reflux disease (GORD/GERD), gastric and duodenal ulcers, and Zollinger-Ellison syndrome.
Adverse effects Diarrhoea, nausea, vomiting, constipation, rash, headaches.

Aciphex®

Rabeprazole, see there.
References in periodicals archive ?
On March 26, 2013, the US Food and Drug Administration approved ACIPHEX Sprinkle Delayed-Release Capsules 5mg and 10mg for the treatment of Gastroesophageal Reflux Disease (GERD) in children 1 to 11 years of age for up to 12 weeks.
When PPIs first hit the market in the 1980s, the acid-blocking pills--sold as Nexium, Prilosec and Aciphex, among other brand names--looked like wonder drugs.
Aside from Prevacid, other well-known proton pump inhibitors are Nexium (esomeprazole), Prilosec (omeprazole), Protonix (pantopra-zole) and Aciphex (rabeprazole).
For patients taking daily aspirin, doctors sometimes prescribe a proton pump inhibitor, such as Nexium, Prilosec, or Aciphex, which suppresses production of stomach acid and lowers the risk of bleeding.
Others include popular brands such as Nexium, Prilosec, Protonix, and Aciphex.
The patient reported taking the following medications: Aciphex 20 mg as needed for acid reflux; Aspirin 81 mg; Benadryl 50 mg; Catapres .
Among the company's mainstay products, Alzheimer's disease treatment Aricept and anti-ulcer drug Pariet, known as Aciphex in the United States, sold particularly well, said Eisai.
TABLE: SIMILAR SOUNDING DRUG NAMES THAT COULD RESULT IN A MEDICATION ERROR Drug Name Confused With Abelcet Amphotericin B Accupril Aciphex Acetazolamide Acetohexamide Aciphex Aricept Aciphex Accupril Activase TNKase Actonel Actos Adderall Inderal Advicor Altocor Aggrastat Argatroban Adapted from Medication Safety Alert.
The survey asked each plan for information about restrictions on five drugs: Advair, an asthma medication; Norvasc, a blood-pressure medication; Aciphex, a heartburn medication; Lexapro, an anti-depressant and anti-anxiety medication; and Ativan, another anti-anxiety medication.
Food and Drug Administration documents, and nearly 100,000 were prescribed similar "proton pump inhibitor" (PPI) heartburn drugs such as Prevacid, Nexium, Protonix, and Aciphex.
Prilosec (omeprazole), Prevacid (lansoprazole), Protonix (pantoprazole), Aciphex (rabeprazole), and Nexium (esomeprazole) are available by prescription only.