acinic cell carcinoma
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a·cin·ic cell ad·e·no·car·ci·no·ma
an adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands.
acinic cell carcinomaBreast
An extremely rare carcinoma that is morphologically identical to the same-named tumours of the salivary glands. There is little known about their behaviour, but they do metastasise to regional lymph nodes and may be fatal.
Microglandular adenosis, apocrine carcinoma.
A usually low-grade, slowly growing salivary (80% are parotid) gland carcinoma with serous acinar cell differentiation. It comprises 1% to 6% of salivary gland tumours, and 10% to 17% of all salivary gland malignancies. In some series it is more common in females, in others, men; it peaks in the 5th decade; 3% are bilateral.
Radiation exposure, familial predisposition, wood dust inhalation.
Outcomes are worse with larger tumours, incomplete excision, deep lobe involvement and MIB proliferation index of > 10%.
5-year survival, 90%; 20-year-survival, 55%; 12–35% recur, 8% metastasise.
Pain at presentation, fixation of tissue to other structures, gross invasion, focal necrosis, perineural invasion, histologic features: desmoplasia, atypia/pleomorphism, increased mitotic activity. Prognosis is better if the tumour nodules are well-circumscribed, microcystic and have lymphoid follicles.
Usually wide local excision suffices; complete first-time surgical excision is critical to cure.
acinic cell carcinomaA low-grade salivary gland malignancy Epidemiology ACC comprises 1–3% of all salivary gland tumors; ♂ predominance; peaks in 3rd decade Management Usually adequately treated with wide local excision Prognosis 5-yr survival, 90%; 20-yr survival, 55%
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the mammary gland, uterus, intestinal tract, skin and tongue.
acinic cell carcinoma
locally invasive salivary gland tumors of dogs, and rarely other species, composed of glandular epithelium in an acinar pattern.
adenocystic carcinoma, adenoid cystic carcinoma
carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
see apocrine tumors.
basal cell carcinoma
an epithelial tumor of the skin that seldom metastasizes but has potential for local invasion and destruction. Common in dogs and cats.
carcinoma that histologically exhibits both basal and squamous elements.
carcinoma of the lung, so called because it arises from the epithelium of the bronchial tree.
primary carcinoma of the liver originating in bile duct cells.
cylindrical cell carcinoma
carcinoma in which the cells are cylindrical or nearly so.
a highly malignant primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad.
that in which the cells tend to differentiate in the same way as those of the epidermis; i.e. they tend to form prickle cells and undergo cornification.
giant cell carcinoma
carcinoma containing many giant cells.
primary carcinoma of the liver cells.
Hürthle cell carcinoma
see hürthle cell tumor.
carcinoma in situ
a neoplastic entity wherein the tumor cells have not invaded the basement membrane but are still confined to the epithelium of origin; popularly applied to such cells in the uterine cervix.
a bronchogenic tumor of undifferentiated (anaplastic) cells of large size.
that composed mainly of epithelial elements with little or no stroma.
adenocarcinoma producing significant amounts of mucin.
carcinoma in which there are papillary excrescences; called also papillocarcinoma.
carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma.
an undifferentiated carcinoma.
carcinoma of skin
squamous cell carcinomas occur on the third eyelid, cornea or the eyelid of cattle and horses, on the penis and prepuce of horses, from the mucosa of the frontal sinus to invade the horn core of cattle (called also horn cancer), on the ears of sheep, on the vulva of ewes when the tail is docked too short. In goats the ears, udder, base of the horn and perineum are also susceptible sites. The tumors grow rapidly, show considerable invasiveness and often metastasize to local lymph nodes. In dogs and cats, squamous cell carcinomas are common, particularly on the face and pinnae of white cats. See also squamous cell carcinoma (below).
a radiosensitive tumor composed of clusters of small, oval, undifferentiated cells that have hyperchromatic nuclei and scant cytoplasm and are typically bronchogenic. Called also oat-cell carcinoma.
spindle cell carcinoma
squamous cell carcinoma marked by fusiform development or rapidly proliferating cells.
squamous cell carcinomas occur in the stomach of the horse and the bovine rumen. The associated clinical syndrome in the horse is one of indigestion and weight loss. Metastasis occurs commonly. In cows there may be vagus indigestion or chronic tympany of the rumen.
transitional cell carcinoma
occurs mainly in the urinary bladder of older dogs. Several structural types may be observed: papillary, polypoid, fungoid or sessile. Metastasis to regional lymph nodes and lungs is possible.
occurs rarely in mares and doe goats.