B and C--one-week post-exposure snails showing the loss of acinar (a) organization, with a large amount of amorphous material (ma) in the acini, vacuolization of acinar cells
, the irregular nucleus (not visible in some cells), and increase of the inter-acinar space; D--Snails in the third week after exposure, in which histopathological changes observed in the early of prepatent period are still present; E--Gonadal tissues of an uninfected snail with normal organization and gametogenesis activity, indicated by the large number of spermatozoa and oocytes (ov) in different developmental stages; F--Ovotestis of infected snail (third week after exposure), presenting normal tissue organization, with many developing spermatozoa (s).
They found that NSAIDs are able to directly inhibit mitogen-induced proliferation of pancreatic acinar cells
. The findings from that study do not explain the link between chronic NSAID use and PAM in humans.
TNF-[alpha] is a polyphonic cytokine and acts as a central regulator of inflammation (20) and is mainly secreted by monocytes and macrophages but also released by pancreatic acinar cells
after an inflammatory trigger (21).
EGF is absent in salivary acinar cells
.18 EGF also positively regulates the effect of alpha-6 integrin.
The world health organization (WHO) described ACC as a malignant epithelial neoplasm of the salivary glands in which at least few neoplastic cells show serous acinar cell
differentiation characterized by cytoplasmic zymogen secretory granules.
Mechanically, after release, noradrenaline binds to the beta-adrenergic receptor on the acinar cells
of the salivary glands, which induces an elevation of intracellular cyclic adenosine monophosphate followed by sAA secretion from the acinar cells
Miura et al., "Xanthine oxidase-mediated in response to cerulein in intracellular oxidative stress rat pancreatic acinar cells
," Pancreas, vol.
Simultaneously, TR[beta] also promoted the proliferation of pancreatic exocrine acinar cells
. However, the role that TR[alpha] seemed to play is more important, since they have a role in transforming elastase-expressing pancreatic acinar cells
into synthesized insulin-producing cells.
Secretory granules first appeared in the cell apex of the luminal acinar cells
at this stage of prenatal life (Fig.
The exocrine acinar cells
were, however, well stained.
(38) Finally, it should be noted that parenchymal cells such as hepatocytes (39) and pancreatic acinar cells
express functional NOD1; (12-14) in the latter case, sensing of commensal organism-derived PGN by NOD1 mediates acute and chronic pancreatitis as discussed in greater detail below.
Autophagy in pancreatic acinar cells
in caerulein-treated mice: immunolocalization of related proteins and their potential as markers of pancreatitis.