They confirmed experimentally in vivo and in vitro that decreasing pH (acidifying) increases the sensitivity of the acinar cells
to zymogen activation.
DP-b99 interferes with several fundamental pathological processes relevant for pancreatitis such as inappropriate calcium-initiated intracellular activation of proteolytic enzymes in acinar cells
and activation of trypsinogen to trypsin, which cause pancreatic tissue damage.
produce and store proteases, amylase and lipase, while ductal cells manufacture bicarbonate-rich fluid.
Advancements have been made in regards to identifying extracellular markers specific to pancreatic cell subtypes, consisting of monoclonal antibodies that recognize the surface of endocrine, alpha, duct and acinar cells
Histopathologic examination of the infraorbital sinus (Fig 3) revealed a mass composed of polygonal cells with frequent arrangement into tubular and acinar cells
, structures indicative of glandular differentiation.
The second study demonstrates that acinar cells
, pancreatic cells that do not normally produce insulin, can be converted to functional beta cells, a potential new avenue for treating the disease.
Helpful distinguishing features include the characteristic monotony, the "salt-and-pepper" chromatin pattern of neuroendocrine tumors, and the lack of other cell lineages, such as acinar cells
or squamid corpuscles, which are present in pancreatoblastoma.
For example, the islets of Langerhans, where the cells of the pancreas are produced, are far different from the acinar cells
that make up the stomach.
Invivo stimulation of rat pancreatic acinar cells
by infusion of secretin.
Intracellular calcium diffusion are very common and have been reported in a large variety of cell types such as: cardiac Myocytes , neuron [2,14],astrocytes , hepatocytes , pancreatic acinar cells
, Fibroblasts cell  etc.
2+] signaling in injury of isolated acinar cells
and pancreatitis model in lipoprotein lipase deficient mice.
Banting thought that ligating the pancreatic ducts of the source animal would allow the acinar cells
to degenerate; otherwise, pancreatic enzymes might digest the anti-diabetic substance if it was present in the pancreatic extract.