108) Otherwise, only rare cases of pancreatic
acinar cell carcinoma (including mixed acinar ductal carcinoma and mixed acinar neuroendocrine carcinoma) have been found to show albumin positivity.
The next most common type,
acinar cell carcinoma of the pancreas, arises in the clusters of the cells that produces these enzymes, and represents 5% of exocrine cancers.
The final diagnoses of the lesions were as follows: PC (n = 109);
acinar cell carcinoma (n = 2); inflammatory mass (n = 11); neuroendocrine tumor (NET) (n = 8); AIP (n = 9); invasive intraductal papillary mucinous carcinoma (IPMC) (n = 5); metastatic lesions (n = 2: lung cancer 1, melanoma 1); and intraductal tubular tumor (ITT) (n = 1) (Table 1).
8) Other differentials include pancreatoblastoma and
acinar cell carcinoma which can be distinguished by their clinical and morphoimmunophenotypic characteristics.
In conclusion, we propose that heterotopic pancreatic
acinar cell carcinoma should be considered as a possibility when considering the differential diagnosis in patients presenting with a duodenal mass.
Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature.
Histological results were consistent with a pure
acinar cell carcinoma.
The incidences of
acinar cell carcinoma and adenoma or carcinoma (combined) exceeded those within the historical control range (overall incidence of acinar cell adenoma, 1 of 207 or 0.
However, this PSA reactivity has also been described in
acinar cell carcinoma of the pancreas [8].
Histologically,
acinar cell carcinoma consists of acinar, trabecular, or solid proliferations of uniform tumor cells with diffuse granular cytoplasm.
Differential diagnosis includes nonfunctional pancreatic endocrine tumor,
acinar cell carcinoma, solid pseudopapillary tumor and adenocarcinoma (15).
However,
acinar cell carcinoma are rare, comprising no more than 1% to 2% of all pancreatic neoplasms, (4,5,6) In an population based study in USA total of 672 patients were identified in comparison to 58,526 of pancreatic adenocarcinoma which were diagnosed.
