acetylcholinesterase inhibitors

acetylcholinesterase inhibitors

Drugs that block the action of the enzyme ACETYLCHOLINESTERASE which quickly breaks down the neurotransmitter acetylcholine. This neurotransmitter is the linking agent between nerve cells in the outer layer (cortex) of the brain. The early impairment of cognitive function found in a common forms of dementia known as dementia with Lewy bodies (DLB) is associated with a reduction in acetylcholine levels. These drugs, by inhibiting, acetylcholine breakdown, have been found helpful in reducing the severity of the early stages of dementia. They cannot be expected to cure or even delay progress of the dementia. The drug group includes DONEPEZIL, GALANTAMINE and RIVASTIGMINE.
References in periodicals archive ?
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products.
Verpoorte, "Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining," Journal of Chromatography A, vol.
Yirmiya, "Acetylcholinesterase inhibitors reduce brain and blood interleukin-1[beta] production," Annals of Neurology, vol.
Treatment with acetylcholinesterase inhibitors may lead to bradycardia by potentiating cardiac vagal activity [20].
Yirmiya, "Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production," Annals of Neurology, vol.
Villalobos et al., "Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease," European Journal of Pharmacology, vol.
Shidu Yan, "Acetylcholinesterase inhibitors: structure based design, synthesis pharmacophore modeling, and virtual screening," Journal of Chemical Information and Modelling, vol.
Pohanka, "Acetylcholinesterase inhibitors: a patent review (2008 present)," Expert Opinion on Therapeutic Patents, vol.
Li, "Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors," Bioorganic & Medicinal Chemistry, vol.
Reversible acetylcholinesterase inhibitors are used as initial treatment for MG and pyridostigmine is the most widely used drug.
TLC bioautographic method has been modified to detect acetylcholinesterase inhibitors. In this method TLC plate and 1- naphthyl acetate were used as a substrate.

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