acetylcholine receptor


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Acetylcholine Receptor

A 250-kD nicotinic receptor which undergoes continuous turnover and renewal, a feature that explains the complete recovery of these receptors when damaged by autoimmune antibodies in myasthenia gravis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

acetylcholine receptor

An ion channel that opens when acetylcholine binds to it, so converting chemical diffusion into an electrical signal. Also known as the nicotinic acetylcholine receptor.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.
The muscarinic acetylcholine receptors are drug targets for neurodegenerative diseases.
Nicotinic acetylcholine receptors have also been implicated in the activation of muscles that control sea urchin spine movement (Morales et al., 1989), and spine movement is also an integral feature of the righting response.
Haga, "Palmitoylation of muscarinic acetylcholine receptor m2 subtypes: reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail," Archives of Biochemistry and Biophysics, vol.
In this meta-analysis, no statistical significant difference was found between [alpha]7-nicotinic acetylcholine receptor agonists and placebo for overall cognitive deficits and negative symptoms in patients with schizophrenia.
Acetylcholine Receptors. AChRs were visualized and quantified in all groups of mice (Figure 3).
It is characterized by decrease in the number of available nicotinic acetylcholine receptors at postsynaptic membrane due to presence of pathogenic autoantibodies [1, 2].
Nonfunctioning acetylcholine receptors are resistant to depolarizing agents like succinylcholine and paralysis is prolonged when achieved with higher doses [12].
We provide evidence that the effect of CCL3 is mediated via CCR1 and calcium-independent phospholipase A2 (iPLA2), release of a soluble small mediator and nicotinic acetylcholine receptors (nAChR) containing subunits a7 and a9.
We have examined whether APN attenuates learning and memory impairments induced by SCO (1 mg/kg, i.p.), a muscarinic acetylcholine receptor antagonist, by conducting Y-maze, Morris water-maze, and passive avoidance tests.
Abbreviations [alpha]7nAChR: [alpha]7 nicotinic acetylcholine receptor BBB: Blood-brain barrier ICH: Intracerebral hemorrhage IL-6: Interleukin-6 JAK2: Janus kinase 2 PBS: Phosphate buffered saline SEM: Standard error of the mean STAT3: Transducer and activator of transcription 3 TNF-[alpha]: Tumor necrosis factor-[alpha].
A heterozygous C>T missense mutation at nucleotide 865 in acetylcholine receptor epsilon-subunit (CHRNE) gene that causes a leucine-to-phenylalanine substitution at position 289 (L289F) was found.