Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor
The muscarinic acetylcholine receptors
are drug targets for neurodegenerative diseases.
Nicotinic acetylcholine receptors
have also been implicated in the activation of muscles that control sea urchin spine movement (Morales et al., 1989), and spine movement is also an integral feature of the righting response.
Haga, "Palmitoylation of muscarinic acetylcholine receptor
m2 subtypes: reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail," Archives of Biochemistry and Biophysics, vol.
In this meta-analysis, no statistical significant difference was found between [alpha]7-nicotinic acetylcholine receptor
agonists and placebo for overall cognitive deficits and negative symptoms in patients with schizophrenia.
. AChRs were visualized and quantified in all groups of mice (Figure 3).
It is characterized by decrease in the number of available nicotinic acetylcholine receptors
at postsynaptic membrane due to presence of pathogenic autoantibodies [1, 2].
Nonfunctioning acetylcholine receptors
are resistant to depolarizing agents like succinylcholine and paralysis is prolonged when achieved with higher doses .
We provide evidence that the effect of CCL3 is mediated via CCR1 and calcium-independent phospholipase A2 (iPLA2), release of a soluble small mediator and nicotinic acetylcholine receptors
(nAChR) containing subunits a7 and a9.
We have examined whether APN attenuates learning and memory impairments induced by SCO (1 mg/kg, i.p.), a muscarinic acetylcholine receptor
antagonist, by conducting Y-maze, Morris water-maze, and passive avoidance tests.
Abbreviations [alpha]7nAChR: [alpha]7 nicotinic acetylcholine receptor
BBB: Blood-brain barrier ICH: Intracerebral hemorrhage IL-6: Interleukin-6 JAK2: Janus kinase 2 PBS: Phosphate buffered saline SEM: Standard error of the mean STAT3: Transducer and activator of transcription 3 TNF-[alpha]: Tumor necrosis factor-[alpha].
A heterozygous C>T missense mutation at nucleotide 865 in acetylcholine receptor
epsilon-subunit (CHRNE) gene that causes a leucine-to-phenylalanine substitution at position 289 (L289F) was found.