Acetyl-l-Carnitine


Also found in: Acronyms.

Acetyl-l-Carnitine

Alternative A form of carnitine which may metabolise lipofuscin and age-related pigment deposits; it is claimed to attenuate age-associated memory loss and Alzheimer’s disease, and increase longevity.
Source Meats—beef, chicken, pork—dairy products, fruits, vegetables, grains
Physiology An acetylated metabolic byproduct of l-carnitine and acetyl-CoA, which is produced within mitochondria during strenuous exercise. ALCAR is a potent antioxidant and nutrient which helps transport fatty acids across lipid membranes into mitochondria, rejuvenating membranes and effete enzymes.
References in periodicals archive ?
Action of Acetyl-L-Carnitine in Neurodegeneration and Alzheimer's Disease.
NUTRIENTS TO COMBAT ALZHEIMER'S DISEASE Nutrients with Strong Evidence from Human Studies Acetyl-L-carnitine Lipoic acid Panax ginseng N-acetyl cysteine (NAC) Huperzine A Omega-3 fatty acids Vitamin D Ginkgo biloba Nutrients with Strong Evidence from Epidemiological Studies Coffee Vitamin E Magnesium Nutrients with Strong Laboratory and Theoretical Evidence B vitamins Blueberry extracts CoQ10 PQQ Curcumin Grape seed extract Green tea Resveratrol Vinpocetine Ashwagandha LE: Are there any dietary or lifestyle strategies to reduce the risk of Alzheimer's?
Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats.
An animal dementia model was established and the effect of acetyl-L-carnitine on cognitive deficit was examined with the dementia model.
Repeated acetyl-L-carnitine administration increases phosphor-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phosphor-Thr75 DARPP-32 levels in rat striatum.
If you buy ALCAR alone, be sure the label says acetyl-L-carnitine and not just plain L-carnitine.
The dietary supplement acetyl-L-carnitine may help improve mental function in older adults, according to a study published in the December 2007 issue of The American Journal of Clinical Nutrition.
* Acetyl-L-carnitine. This dietary supplement appeared to reduce MS patients' fatigue severity, and no such effect was seen with the more standard MS fatigue medication amantadine in a small study.
The pills also contained a building block for glutathione, an antioxidant made by the body; acetyl-L-carnitine; and S-adenosyl methionine.
The authors suggested that the suppressed platelet activity was caused by intracellular hydrolysis of propionyl-L-carnitine to L-carnitine with subsequent depletion of acetyl-CoA as a result of acetyl-L-carnitine formation (13).
In HIV+ patients with this condition, blood levels of a natural substance called acetyl-L-carnitine (ALCAR) tend to be lower.
Carnitine (also known as L-carnitine and acetyl-L-carnitine) is an amino acid that is made in the liver and kidneys, it is also found in meat and dairy products, (25) but there is very little found in plant foods.