ACEI


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ACEI

Abbreviation for angiotensin-converting enzyme inhibitors.

ACE inhibitor

Angiotensin-converting enzyme inhibitor. Any of a family of drugs used to manage hypertension and reduce congestive heart failure (CHF)-related mortality and morbidity.

Examples
Bepridil, captopril, enalapril, lisionopril, losartan, quinapril, ramipril.

ACE inhibitor Effects in Heart Disease
Cardioprotective effects
• Restores balance between myocardial O2 supply and demand;
• Reduces left ventricular preload and afterload;
• Reduces left ventricular mass;
• Reduces sympathetic stimulation.
Vasculoprotective effects
• Antiproliferative and antimigratory effects on smooth muscle and inflammatory cells;
• Antiplatelet effects;
• Improved arterial compliance and tone;
• Improved and/or restored endothelial function;
• Antihypertensive;
• Possible antiatherosclerotic effect. 

Pros
ACEIs are cardioprotective and vasculoprotective; cardioprotective effects include improved haemodynamics and electric stability, reduce sympathetic nervous system (SNS) activity and reduce left ventricular mass; vasculoprotective benefits include improved endothelial function, vascular compliance and tone, and direct antiproliferative and antiplatelet effects. ACEIs also stimulate prostaglandin (PG) synthesis, reduce the size of MIs, and reduce reperfusion injury and complex ventricular arrhythmias.

ACEIs are the treatment of choice in CHF with systolic dysfunction; they are vasodilators which decrease preload and afterload. ACEI-induced reduction in angiotensin II inhibits the release of aldosterone, which in turn reduces sodium and water retention which, by extension, reduce preload; ACEIs improve haemodynamics of CHF by reducing right atrial pressure, pulmonary capillary wedge pressure, arterial BP, as well as pulmonary and systemic vascular resistance; ACEIs increase cardiac and stroke indices by the left ventricle and reduce the right ventricular end-diastolic volumes, thereby increasing cardiac output, while simultaneously reducing cardiac load and myocardial O2 consumption.
 
Adverse effects
• Idiopathic—e.g., rashes, dysgeusia, BMsuppression.
• Class-specific—e.g., hypotension, renal impairment, hyperkaleamia, cough, angioneurotic oedema (the latter 2 of which are mediated by small vasoactive substances—e.g., bradykinin, substance P, and PG-related factors).
References in periodicals archive ?
Up to 5% of patients do not tolerate ACEI, primarily due to cough, and AE occurs in 0.1% to 0.7% of patients taking ACEI (11).
Hardin believes that her leadership skills, knowledge, and international experience will assist her to fulfill her duties as Secretary, and help her to expand ACEI's mission to support the global community through childhood education and the professional growth of educators.
What do you hope to see in the emerging educators of ACEI?
Finally, on behalf of ACEI's Executive Board, we wish you every happiness for the holiday season and look forward to working with you in the future to make the world a better place for our children!
We want to do everything we can to help you promote ACEI membership to your colleagues, fellow teachers, students, and others concerned about the health, welfare, and education of children.
Each award recipient will receive recognition on the ACEI website, in the Leader News and the ACEI Exchange, a Certificate of Excellence with a $300 cash award, and one (1) free conference registration.
Previous to joining ACEI, Mindi served as the Development Associate for Global Action for Children (GAC) in Washington, D.C., where she assisted with the strategic management of fundraising activities.
After a 100% success rate with the graduation of Class I candidates, ACEI is preparing for Class II of Leadership ACEI by opening up nominations for mentors and fellows.
Since joining the association in 2004, Jessica has held several ACEI positions, on the state and national levels.
Jacqueline Blackwell, former President of ACEI, and a loyal member for more than 35 years, was presented with the prestigious Patty Smith Hill Award at the 2010 ACEI Annual International Conference in Phoenix, Arizona.
ACEI is pleased to announce the election of Debora Wisneski to the position of President-Elect.
The Nominations Committee roster listed in the 2009/10 Yearbook, published in the Fall 2009 ACEI Exchange, was incomplete.