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Related to Accolate: Accutane, zafirlukast, Singulair



Pharmacologic class: Leukotriene receptor antagonist

Therapeutic class: Antiasthmatic, bronchodilator

Pregnancy risk category B


Antagonizes activity of three leukotrienes at specific receptor sites in airway smooth muscle, inhibiting inflammation


Tablets (coated): 10 mg, 20 mg

Indications and dosages

Prophylaxis and long-term treatment of asthma

Adults and children ages 12 and older: 20 mg P.O. b.i.d.

Children ages 5 to 11: 10 mg P.O. b.i.d.

Off-label uses

• Exercise-induced bronchospasm

• Chronic urticaria


• Hypersensitivity to drug or its components

• Hepatic impairment, including hepatic cirrhosis


Use cautiously in:

• acute asthma attacks

• concurrent use of warfarin

• patients older than age 55

• pregnant patients

• breastfeeding patients (use not recommended)

• children younger than age 5 (safety not established).


• Give at least 1 hour before or 2 hours after a meal.

Adverse reactions

CNS: headache, dizziness, asthenia, insomnia, depression (especially in children and adolescents)

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia

Hepatic: hepatic dysfunction including liver failure and death (rare)

Musculoskeletal: joint or back pain, myalgia

Other: fever, infection, pain


Drug-drug. Aspirin: increased zafirlukast blood level

Erythromycin, theophylline: decreased zafirlukast blood level

Warfarin: increased warfarin effects, greater risk of bleeding

Drug-food. Any food: decreased rate and extent of zafirlukast absorption

Patient monitoring

• Assess patient's respiratory status to help evaluate drug efficacy.

Monitor liver function tests closely; watch for signs and symptoms of liver dysfunction.

Patient teaching

• Tell patient to take at least 1 hour before or 2 hours after a meal.

• Advise patient to take exactly as prescribed, even if he is symptom-free.

Tell patient to immediately report asthma attack. Advise him not to use drug for rapid relief of bronchospasm.

• Instruct patient to continue taking other asthma drugs unless prescriber directs otherwise.

Instruct patient to immediately report signs and symptoms of liver dysfunction (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, flulike symptoms, or right upper quadrant abdominal pain).

• Instruct patient or caregiver to report insomnia or depression.

• Instruct female patient to consult prescriber if she plans to breastfeed.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.


A trademark for the drug zafirlukast.


Zafirkulast, see there.

Zafirlukast (Accolate)

An inhibitor that prevents leukotrienes from binding to cell receptors; taken over time, zafirlukast can help reduce or prevent asthma symptoms.
References in periodicals archive ?
According to IMS Health data, annual US sales for Accolate are approximately USD50m (EUR36.
This agreement covers distribution of the authorised generic version of AstraZeneca's Accolate (zafirlukast), which is indicated for the prophylaxis and chronic treatment of asthma in adults and children aged five years and older.
The FDA is also reviewing reports of suicide and behavioral changes in people who took AstraZeneca Plc's Accolate and Critical Therapeutics Inc.
COMMONLY PRESCRIBED MEDICATIONS AVAILABLE THROUGH PATIENT ASSISTANCE PROGRAMS Drug Manufacturer Accolate AstraZeneca Azmacort KOS Effexor Wyeth Lipitor Pfizer Zetia Merck Adapted from Commonly Prescribed Medications Available Through Patient Assistance Programs.
Tablets Accolate Prescription (zafirlukast), Singulair (montelukast), Zyflo (zileuton) Anticholinergics.
Ayckbourn is probably horrified at finding that his work is now routinely dissected for school examination purposes, but I suspect that it is an accolate that had to come.
4 per cent to 2640p as it warned doctors in Canada about potential liver problems associated with its asthma drug Accolate.
Zeneca, for example, had to modify its Accolate TV ad because the actions of the characters in it implied an indication--for exercise-induced asthma--that the product didn't warrant.
Although Astra has a number of well-established anti-asthma products, Zeneca had no such activities until the recent development of Accolate, a leukotriene receptor antagonist (LTRA).
Zeneca Accolate Drug Interaction Studies Should Be Performed Prior to Reconsideration for Approval, F-D-C REP.
In November, 1996, Accolate became the first product in the newest class of asthma drugs (leukotriene modifiers) approved by the Food and Drug Administration.
Accolate and Singulair are taken in tablet form and help prevent inflammation of the lining of the airways in the lungs - the underlying cause of asthma.