Accolate


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Related to Accolate: Accutane, zafirlukast, Singulair

zafirlukast

Accolate

Pharmacologic class: Leukotriene receptor antagonist

Therapeutic class: Antiasthmatic, bronchodilator

Pregnancy risk category B

Action

Antagonizes activity of three leukotrienes at specific receptor sites in airway smooth muscle, inhibiting inflammation

Availability

Tablets (coated): 10 mg, 20 mg

Indications and dosages

Prophylaxis and long-term treatment of asthma

Adults and children ages 12 and older: 20 mg P.O. b.i.d.

Children ages 5 to 11: 10 mg P.O. b.i.d.

Off-label uses

• Exercise-induced bronchospasm

• Chronic urticaria

Contraindications

• Hypersensitivity to drug or its components

• Hepatic impairment, including hepatic cirrhosis

Precautions

Use cautiously in:

• acute asthma attacks

• concurrent use of warfarin

• patients older than age 55

• pregnant patients

• breastfeeding patients (use not recommended)

• children younger than age 5 (safety not established).

Administration

• Give at least 1 hour before or 2 hours after a meal.

Adverse reactions

CNS: headache, dizziness, asthenia, insomnia, depression (especially in children and adolescents)

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia

Hepatic: hepatic dysfunction including liver failure and death (rare)

Musculoskeletal: joint or back pain, myalgia

Other: fever, infection, pain

Interactions

Drug-drug. Aspirin: increased zafirlukast blood level

Erythromycin, theophylline: decreased zafirlukast blood level

Warfarin: increased warfarin effects, greater risk of bleeding

Drug-food. Any food: decreased rate and extent of zafirlukast absorption

Patient monitoring

• Assess patient's respiratory status to help evaluate drug efficacy.

Monitor liver function tests closely; watch for signs and symptoms of liver dysfunction.

Patient teaching

• Tell patient to take at least 1 hour before or 2 hours after a meal.

• Advise patient to take exactly as prescribed, even if he is symptom-free.

Tell patient to immediately report asthma attack. Advise him not to use drug for rapid relief of bronchospasm.

• Instruct patient to continue taking other asthma drugs unless prescriber directs otherwise.

Instruct patient to immediately report signs and symptoms of liver dysfunction (nausea, anorexia, fatigue, lethargy, pruritus, jaundice, flulike symptoms, or right upper quadrant abdominal pain).

• Instruct patient or caregiver to report insomnia or depression.

• Instruct female patient to consult prescriber if she plans to breastfeed.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

Accolate

(ăk′ə-lāt′)
A trademark for the drug zafirlukast.

Accolate®

Zafirkulast, see there.

Zafirlukast (Accolate)

An inhibitor that prevents leukotrienes from binding to cell receptors; taken over time, zafirlukast can help reduce or prevent asthma symptoms.
References in periodicals archive ?
M2 EQUITYBITES-November 23, 2010-Par Pharmaceutical Companies Inc commences supply of authorised generic version of Accolate in US(C)2010 M2 COMMUNICATIONS http://www.m2.com
There are two other members of this class of medications, zafirlukast (Accolate) and zileuton (Zyflo).
The oral medications that patients in the study were using were the leukotriene modifiers zafirlukast (Accolate), montelukast (Singulair), and zileuton (Zyflo).
The drugs affected by the FDA announcement include montelukast (Singulair), zafirlukast (Accolate) and zieuton (Zyflo and Zyflo CR).
The agency said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo, Zyflo CR).
The FDA, which issued the call in mid June, said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo, Zyflo CR).
Of the 96 women who took a leukotriene antagonist, 72 received montelukast; 22, zafirlukast (another leukotriene antagonist marketed as Accolate); and 2, both medications.
"Both are port cities and Liverpudlians too are very warm-hearted, honest and open, so there is the same feeling you can chat to strangers you meet on the street." The first person to be awarded with the accolate was departing Culture Company director Kris Donaldson, a Californian..
Zafirlukast- Zafirlukast, also known as Accolate, is a synthetic asthma prophylactic agent.
Montelukast (Singulair) and zafirlukast (Accolate) are two examples of leukotriene modifiers.
Hip sales were driven by sales of X3 polyethylene and Accolade cementless hip products in the United States, as well as solid sales for the Exeter, Trident, X3 polyethylene and Accolate products in Europe, the Pacific region and Latin America.