Disease manifestations include severe failure to thrive, scleroderma-like skin, global lipodystrophy, alopecia, joint contractures, skeletal dysplasia, global accelerated atherosclerosis
with cardiovascular decline, and debilitating strokes.
Still unsettled, however, is the chicken-versus-egg question of whether preeclampsia and other pregnancy complications represent the initial expression of an adverse phenotype associated with early development of cardiovascular disease or the complications injure the vascular endothelium and thereby trigger accelerated atherosclerosis
. In any case, markers of endothelial activation have been documented up to 15 years after an episode of preeclampsia, she said.
The acquired form of CAF can be found in thoracic trauma and iatrogenic factors such as coronary angioplasty and endomyocardial biopsies. Shear stress due to increased flow velocity and turbulence may predispose a vessel to accelerated atherosclerosis
and thrombosis, resulting in increased intraluminal pressure and formation of aneurysmal dilatation. Although acquired CAFs are often accompanied with aneurysmal dilatation, formation of a saccular aneurysm with diameter exceeding 50 mm is extremely rare.
[10,11] Accelerated atherosclerosis
as well as microvascular disease are the major vascular complications of diabetes, constituting the main cause of morbidity and mortality in this common metabolic disorder.
Davis et al., "Prevalence and correlates of accelerated atherosclerosis
in systemic lupus erythematosus," The New England Journal of Medicine, vol.
There is increasing evidence that ROS induced by NADPH oxidases not only causes cell damage but also acts as second messengers implicated in proliferation, differentiation, and apoptosis, which finally leads to accelerated atherosclerosis
in diabetes .
addressed the methylarginine metabolism in RA patients; in particular, the authors focused on asymmetric dimethyl-arginine (ADMA) and its implication in the accelerated atherosclerosis
both as a surrogate biomarker of ED and as a possible target of treatment.
Scribner, "Accelerated atherosclerosis
in prolonged maintenance hemodialysis," The New England Journal of Medicine, vol.
The finding that plasma urea is the only significant predictor of aortic plaque area fraction in an animal model of CRF-accelerated atherosclerosis (12), suggests that the high levels of urea found in patients under chronic dialysis might play an important role in accelerated atherosclerosis
in this group of patients.
Approaches to supplement SOC1 or mimic native SOCS1 function may have therapeutic effects on accelerated atherosclerosis
They reported higher levels of the HSPG in atherosclerotic lesions and concluded that the HSPG might mediate multiple processes that contribute to accelerated atherosclerosis
. Baker et al.
Ankylosing spondylitis is associated with accelerated atherosclerosis
and increased risk of metabolic syndrome (11-13).