Naltrexone or acamprosate
should be offered as first-line pharmacologic therapy to patients with moderate to severe alcohol use disorder who do not respond to nonpharmacologic therapy alone, according to a practice guideline published by the American Psychiatric Association.
2 gram delayed-release tablets, and over the course of the year the company has launched several other products such as acamprosate
delayed-release tablets, methotrexate tablets, olmesartan tablets and oseltamivir capsules.
It is advisable to start with an FDA-approved medication such as disulfiram for the motivated patient who has a collaborator and desires complete abstinence; naltrexone for a patient who wants to cut down on intake (a long-acting formulation can be used for poorly adherent patients); and acamprosate
for a patient with at least some established sobriety who needs help with post-withdrawal sleep disturbances.
(calcium acetylhomotaurinate, brand name Campral) is an amino acid (homotaurine) derivative.
calcium and nalmefene work by reducing cravings for alcohol.
The evidence for acamprosate
is not quite as strong.
2014): oral and long-acting injectable naltrexone, acamprosate
, and disulfiram.
The anti-craving pill acamprosate
appears to calm stress-related brain chemicals in certain people.
Kranzler referred to a recently published meta-analysis indicating that topiramate had a greater effect than did acamprosate
or naltrexone in people with alcohol use disorders (Alcohol Clin.
This funding supports the continued development of SNC-102, a new formulation of acamprosate
calcium currently being studied in a Phase 2 trial to treat moderate-to-severe tardive dyskinesia (TD).
They found that two drugs, acamprosate
(brand name Campral) and oral naltrexone (brand name Revia), have the best evidence supporting their benefits.
Some patients may be open to receiving treatment by primary care providers, but few drugs are available (naltrexone, acamprosate
, and disulfiram).